BRD-K52850071_JAK3 Inhibitor II_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CD40 CD40 molecule, TNF receptor superfamily member 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPE carboxypeptidase E
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
FAM129A family with sequence similarity 129, member A
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HNMT histamine N-methyltransferase
ITM2C integral membrane protein 2C
KLK5 kallikrein-related peptidase 5
LOC100505650 uncharacterized LOC100505650
MDK midkine (neurite growth-promoting factor 2)
MUC16 mucin 16, cell surface associated
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RNASE6 ribonuclease, RNase A family, k6
S100A8 S100 calcium binding protein A8
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A2 solute carrier family 38, member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX11 SRY (sex determining region Y)-box 11
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BASP1 brain abundant, membrane attached signal protein 1
CDCA4 cell division cycle associated 4
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EIF5A eukaryotic translation initiation factor 5A
FAM46A family with sequence similarity 46, member A
FKBP5 FK506 binding protein 5
GOLGA8A golgin A8 family, member A
HSPA1A heat shock 70kDa protein 1A
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
PTX3 pentraxin 3, long
SERTAD2 SERTA domain containing 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
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