BRD-K52911425_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K52911425_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
C10ORF10 chromosome 10 open reading frame 10
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DDAH2 dimethylarginine dimethylaminohydrolase 2
DPYSL2 dihydropyrimidinase-like 2
EDN1 endothelin 1
EFNA1 ephrin-A1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FOXO4 forkhead box O4
GNB5 guanine nucleotide binding protein (G protein), beta 5
HBP1 HMG-box transcription factor 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
JUP junction plakoglobin
KLF6 Kruppel-like factor 6
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MVP major vault protein
NET1 neuroepithelial cell transforming 1
PDE4C phosphodiesterase 4C, cAMP-specific
PYCARD PYD and CARD domain containing
RAB40B RAB40B, member RAS oncogene family
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SOX4 SRY (sex determining region Y)-box 4
SYF2 SYF2 pre-mRNA-splicing factor
TMSB15A thymosin beta 15a
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AMD1 adenosylmethionine decarboxylase 1
ATR ATR serine/threonine kinase
CDC25A cell division cycle 25A
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
COTL1 coactosin-like F-actin binding protein 1
CTPS1 CTP synthase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPH2 DPH2 homolog (S. cerevisiae)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENDOD1 endonuclease domain containing 1
EXOSC4 exosome component 4
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MAK16 MAK16 homolog (S. cerevisiae)
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MINA MYC induced nuclear antigen
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PER2 period circadian clock 2
PFKP phosphofructokinase, platelet
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRMT1 protein arginine methyltransferase 1
PRR7 proline rich 7 (synaptic)
RHOBTB3 Rho-related BTB domain containing 3
RPP40 ribonuclease P/MRP 40kDa subunit
RRP1B ribosomal RNA processing 1B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SRSF7 serine/arginine-rich splicing factor 7
TEX10 testis expressed 10
TFRC transferrin receptor
TMEM109 transmembrane protein 109
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
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