BRD-K52911425_GDC-0941_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K52911425_GDC-0941_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA5 annexin A5
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
C1S complement component 1, s subcomponent
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CD8A CD8a molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CST3 cystatin C
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
DUSP1 dual specificity phosphatase 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOXN3 forkhead box N3
GATA2 GATA binding protein 2
GSTA1 glutathione S-transferase alpha 1
HIST1H2BG histone cluster 1, H2bg
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KLF4 Kruppel-like factor 4 (gut)
MAGEA3 melanoma antigen family A3
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MTMR11 myotubularin related protein 11
NXT2 nuclear transport factor 2-like export factor 2
PDGFD platelet derived growth factor D
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR4 phospholipid scramblase 4
POSTN periostin, osteoblast specific factor
PRKCQ protein kinase C, theta
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRBC1 T cell receptor beta constant 1
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VGLL4 vestigial-like family member 4
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CHD7 chromodomain helicase DNA binding protein 7
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR24 24-dehydrocholesterol reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
FRMD4B FERM domain containing 4B
HBEGF heparin-binding EGF-like growth factor
HHEX hematopoietically expressed homeobox
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IL1B interleukin 1, beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSLN mesothelin
NOP2 NOP2 nucleolar protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARP2 poly (ADP-ribose) polymerase 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
SDC1 syndecan 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
Funding