BRD-K53414658_tivozanib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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97 genes differentially expressed following the BRD-K53414658_tivozanib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AKAP12 A kinase (PRKA) anchor protein 12
AMDHD2 amidohydrolase domain containing 2
ASS1 argininosuccinate synthase 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
COBL cordon-bleu WH2 repeat protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGLL1 immunoglobulin lambda-like polypeptide 1
IRS2 insulin receptor substrate 2
KIAA0368 KIAA0368
KRT7 keratin 7, type II
LAMP1 lysosomal-associated membrane protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
PRAME preferentially expressed antigen in melanoma
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
S100P S100 calcium binding protein P
SCCPDH saccharopine dehydrogenase (putative)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
TM4SF1 transmembrane 4 L six family member 1
TRIM2 tripartite motif containing 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCL vinculin
ZBTB16 zinc finger and BTB domain containing 16
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ABI1 abl-interactor 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ATG3 autophagy related 3
BICC1 BicC family RNA binding protein 1
BLNK B-cell linker
C7 complement component 7
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CFI complement factor I
CLEC2B C-type lectin domain family 2, member B
CX3CR1 chemokine (C-X3-C motif) receptor 1
DACH1 dachshund family transcription factor 1
DSP desmoplakin
EREG epiregulin
FAM69A family with sequence similarity 69, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
GTF2A2 general transcription factor IIA, 2, 12kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HIST1H4J histone cluster 1, H4j
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL2RB interleukin 2 receptor, beta
IPO13 importin 13
KIF5B kinesin family member 5B
LEPR leptin receptor
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MB myoglobin
MEIS2 Meis homeobox 2
MOXD1 monooxygenase, DBH-like 1
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PLEK pleckstrin
PMM2 phosphomannomutase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RAB25 RAB25, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RTN1 reticulon 1
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SEPP1 selenoprotein P, plasma, 1
SHB Src homology 2 domain containing adaptor protein B
SIRT3 sirtuin 3
SOCS2 suppressor of cytokine signaling 2
SRP54 signal recognition particle 54kDa
TBPL1 TBP-like 1
TM9SF3 transmembrane 9 superfamily member 3
TRAPPC6A trafficking protein particle complex 6A
TUSC3 tumor suppressor candidate 3
YME1L1 YME1-like 1 ATPase
ZNF395 zinc finger protein 395