BRD-K53417444_OTSSP167_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K53417444_OTSSP167_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANOS1 anosmin 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BAD BCL2-associated agonist of cell death
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CD2 CD2 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD4 CD4 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COPS7A COP9 signalosome subunit 7A
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CRELD2 cysteine-rich with EGF-like domains 2
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
E2F2 E2F transcription factor 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
FYB FYN binding protein
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
HIST1H1C histone cluster 1, H1c
HIST1H4H histone cluster 1, H4h
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPB8 heat shock 22kDa protein 8
IL13RA2 interleukin 13 receptor, alpha 2
IL6R interleukin 6 receptor
ITK IL2-inducible T-cell kinase
KANK1 KN motif and ankyrin repeat domains 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5A lysine (K)-specific demethylase 5A
KIAA1551 KIAA1551
LAMP3 lysosomal-associated membrane protein 3
MAOA monoamine oxidase A
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
METRN meteorin, glial cell differentiation regulator
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MXI1 MAX interactor 1, dimerization protein
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
NTS neurotensin
OLFM1 olfactomedin 1
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PCDH7 protocadherin 7
PDE8B phosphodiesterase 8B
PLVAP plasmalemma vesicle associated protein
PON2 paraoxonase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD5 stearoyl-CoA desaturase 5
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCTN1 tectonic family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM164 transmembrane protein 164
TPSAB1 tryptase alpha/beta 1
TRAK2 trafficking protein, kinesin binding 2
TRBC1 T cell receptor beta constant 1
TRIM36 tripartite motif containing 36
TTC3 tetratricopeptide repeat domain 3
TXNL4B thioredoxin-like 4B
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1
ZBED2 zinc finger, BED-type containing 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADGRG2 adhesion G protein-coupled receptor G2
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CIT citron rho-interacting serine/threonine kinase
CSRP1 cysteine and glycine-rich protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
FHL2 four and a half LIM domains 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLS glutaminase
HEATR1 HEAT repeat containing 1
IGFBP5 insulin-like growth factor binding protein 5
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
LBR lamin B receptor
LIMS1 LIM and senescent cell antigen-like domains 1
LY6D lymphocyte antigen 6 complex, locus D
MACF1 microtubule-actin crosslinking factor 1
MBNL2 muscleblind-like splicing regulator 2
MGP matrix Gla protein
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PKM pyruvate kinase, muscle
PROM1 prominin 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPRE protein tyrosine phosphatase, receptor type, E
PXMP2 peroxisomal membrane protein 2, 22kDa
RBBP4 retinoblastoma binding protein 4
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RPL39L ribosomal protein L39-like
SMAD7 SMAD family member 7
SRSF1 serine/arginine-rich splicing factor 1
SRSF5 serine/arginine-rich splicing factor 5
TCF4 transcription factor 4
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TXLNA taxilin alpha
TYMS thymidylate synthetase
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1
Funding