BRD-K53417444_OTSSP167_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K53417444_OTSSP167_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
AQP9 aquaporin 9
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CAPG capping protein (actin filament), gelsolin-like
CCL2 chemokine (C-C motif) ligand 2
CD47 CD47 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPQ carboxypeptidase Q
CRISP3 cysteine-rich secretory protein 3
CTSD cathepsin D
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
ELANE elastase, neutrophil expressed
FBP1 fructose-1,6-bisphosphatase 1
FGR FGR proto-oncogene, Src family tyrosine kinase
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBP1 guanylate binding protein 1, interferon-inducible
GNS glucosamine (N-acetyl)-6-sulfatase
GPX1 glutathione peroxidase 1
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
IFI30 interferon, gamma-inducible protein 30
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL2RG interleukin 2 receptor, gamma
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCTD12 potassium channel tetramerization domain containing 12
LDHB lactate dehydrogenase B
LGALS3 lectin, galactoside-binding, soluble, 3
LY75 lymphocyte antigen 75
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEB2 melanoma antigen family B2
MAN2B1 mannosidase, alpha, class 2B, member 1
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MICB MHC class I polypeptide-related sequence B
MMP12 matrix metallopeptidase 12
MNDA myeloid cell nuclear differentiation antigen
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NLRP2 NLR family, pyrin domain containing 2
NNMT nicotinamide N-methyltransferase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRGN neurogranin (protein kinase C substrate, RC3)
PLA1A phospholipase A1 member A
PLBD1 phospholipase B domain containing 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RCAN1 regulator of calcineurin 1
RRAGD Ras-related GTP binding D
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMHD1 SAM domain and HD domain 1
SCPEP1 serine carboxypeptidase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3YL1 SH3 and SYLF domain containing 1
SKAP2 src kinase associated phosphoprotein 2
SLC22A18 solute carrier family 22, member 18
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STC1 stanniocalcin 1
SULF1 sulfatase 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TLR4 toll-like receptor 4
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSPO translocator protein (18kDa)
TXNL4B thioredoxin-like 4B
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XAF1 XIAP associated factor 1
ZBTB43 zinc finger and BTB domain containing 43

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AEBP1 AE binding protein 1
ANXA3 annexin A3
ANXA7 annexin A7
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
CALML5 calmodulin-like 5
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CD24 CD24 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLTC clathrin, heavy chain (Hc)
CPA3 carboxypeptidase A3 (mast cell)
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
FGG fibrinogen gamma chain
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLRX glutaredoxin (thioltransferase)
GRWD1 glutamate-rich WD repeat containing 1
HEATR1 HEAT repeat containing 1
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
KIAA0101 KIAA0101
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
NR2F2 nuclear receptor subfamily 2, group F, member 2
NXN nucleoredoxin
PCNA proliferating cell nuclear antigen
PLP1 proteolipid protein 1
PNP purine nucleoside phosphorylase
PON2 paraoxonase 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBP4 retinol binding protein 4, plasma
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SORBS1 sorbin and SH3 domain containing 1
SPRR1B small proline-rich protein 1B
SQLE squalene epoxidase
TAGLN transgelin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSPAN13 tetraspanin 13
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
USO1 USO1 vesicle transport factor
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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