BRD-K53417444_OTSSP167_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K53417444_OTSSP167_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOE apolipoprotein E
AQP9 aquaporin 9
ASPN asporin
C6ORF48 chromosome 6 open reading frame 48
C9ORF16 chromosome 9 open reading frame 16
CCL5 chemokine (C-C motif) ligand 5
CD302 CD302 molecule
CD8A CD8a molecule
CDC42 cell division cycle 42
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLU clusterin
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPQ carboxypeptidase Q
CREG1 cellular repressor of E1A-stimulated genes 1
CTSD cathepsin D
CTSL cathepsin L
CTSS cathepsin S
CTSW cathepsin W
CUTA cutA divalent cation tolerance homolog (E. coli)
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DST dystonin
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELF1 E74-like factor 1 (ets domain transcription factor)
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
FAM129A family with sequence similarity 129, member A
FBP1 fructose-1,6-bisphosphatase 1
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA3 GATA binding protein 3
GOLGA8A golgin A8 family, member A
GPR183 G protein-coupled receptor 183
GRN granulin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUSB glucuronidase, beta
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI30 interferon, gamma-inducible protein 30
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
ISYNA1 inositol-3-phosphate synthase 1
LAMP3 lysosomal-associated membrane protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LITAF lipopolysaccharide-induced TNF factor
LY75 lymphocyte antigen 75
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MFAP3L microfibrillar-associated protein 3-like
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT2A metallothionein 2A
MYLK myosin light chain kinase
NQO2 NAD(P)H dehydrogenase, quinone 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUCB1 nucleobindin 1
NUP210 nucleoporin 210kDa
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCCB propionyl CoA carboxylase, beta polypeptide
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PFKL phosphofructokinase, liver
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
PPT1 palmitoyl-protein thioesterase 1
PROS1 protein S (alpha)
PSAP prosaposin
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRD protein tyrosine phosphatase, receptor type, D
QPCT glutaminyl-peptide cyclotransferase
RAB40B RAB40B, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SF1 splicing factor 1
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
SPP1 secreted phosphoprotein 1
SRGN serglycin
SRRM2 serine/arginine repetitive matrix 2
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TKTL1 transketolase-like 1
TMC5 transmembrane channel-like 5
TOMM34 translocase of outer mitochondrial membrane 34
TSPAN3 tetraspanin 3
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
VIM vimentin
XAF1 XIAP associated factor 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ADGRG2 adhesion G protein-coupled receptor G2
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AK1 adenylate kinase 1
ANK2 ankyrin 2, neuronal
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
BLVRA biliverdin reductase A
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CD24 CD24 molecule
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLTC clathrin, heavy chain (Hc)
CPA3 carboxypeptidase A3 (mast cell)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FXYD3 FXYD domain containing ion transport regulator 3
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GLRX glutaredoxin (thioltransferase)
GTPBP4 GTP binding protein 4
HEATR1 HEAT repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO7 importin 7
KLK11 kallikrein-related peptidase 11
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MB myoglobin
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MREG melanoregulin
MSMB microseminoprotein, beta-
NPEPL1 aminopeptidase-like 1
NRIP1 nuclear receptor interacting protein 1
NSG1 neuron specific gene family member 1
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLP1 proteolipid protein 1
PNP purine nucleoside phosphorylase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRE protein tyrosine phosphatase, receptor type, E
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SEC24B SEC24 family member B
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX4 SRY (sex determining region Y)-box 4
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TYMS thymidylate synthetase
XBP1 X-box binding protein 1
Funding