BRD-K53417444_OTSSP167_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-K53417444_OTSSP167_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AKAP9 A kinase (PRKA) anchor protein 9
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMPH amphiphysin
ANKRD36B ankyrin repeat domain 36B
ASPN asporin
BACE2 beta-site APP-cleaving enzyme 2
C1ORF54 chromosome 1 open reading frame 54
C6ORF48 chromosome 6 open reading frame 48
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
COL2A1 collagen, type II, alpha 1
COLEC12 collectin sub-family member 12
CTGF connective tissue growth factor
CTSL cathepsin L
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DST dystonin
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
ECM1 extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
ERBB4 erb-b2 receptor tyrosine kinase 4
FBN2 fibrillin 2
FGFR4 fibroblast growth factor receptor 4
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FZD6 frizzled class receptor 6
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATAD1 GATA zinc finger domain containing 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GREB1 growth regulation by estrogen in breast cancer 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOOK2 hook microtubule-tethering protein 2
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLHL24 kelch-like family member 24
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100272216 uncharacterized LOC100272216
LOC399491
LOX lysyl oxidase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEG3 maternally expressed 3 (non-protein coding)
MEIS1 Meis homeobox 1
METRN meteorin, glial cell differentiation regulator
MFSD10 major facilitator superfamily domain containing 10
MMP9 matrix metallopeptidase 9
MSRB2 methionine sulfoxide reductase B2
MSX1 msh homeobox 1
MT1F metallothionein 1F
MXRA7 matrix-remodelling associated 7
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYLIP myosin regulatory light chain interacting protein
NGRN neugrin, neurite outgrowth associated
NPIPB3 nuclear pore complex interacting protein family, member B3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OBSL1 obscurin-like 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PAX6 paired box 6
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PMS2P1 postmeiotic segregation increased 2 pseudogene 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PMS2P5 postmeiotic segregation increased 2 pseudogene 5
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
PTPRD protein tyrosine phosphatase, receptor type, D
RGS1 regulator of G-protein signaling 1
RPS21 ribosomal protein S21
RPS5 ribosomal protein S5
RSRP1 arginine/serine-rich protein 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SALL1 spalt-like transcription factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SF1 splicing factor 1
SH3YL1 SH3 and SYLF domain containing 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TCF4 transcription factor 4
TCTA T-cell leukemia translocation altered
TFPI2 tissue factor pathway inhibitor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARG1 arginase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CCNA1 cyclin A1
CCNA2 cyclin A2
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLTC clathrin, heavy chain (Hc)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP7 dual specificity phosphatase 7
ELOVL1 ELOVL fatty acid elongase 1
FERMT1 fermitin family member 1
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IL32 interleukin 32
KIAA1033 KIAA1033
KLF5 Kruppel-like factor 5 (intestinal)
KLK6 kallikrein-related peptidase 6
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PNP purine nucleoside phosphorylase
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RNMT RNA (guanine-7-) methyltransferase
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNRG synergin, gamma
TAGLN2 transgelin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TRIM29 tripartite motif containing 29
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XBP1 X-box binding protein 1
XPO7 exportin 7
Funding