BRD-K53610452_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K53610452_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
APOD apolipoprotein D
ATP10D ATPase, class V, type 10D
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
CCNG2 cyclin G2
CD24 CD24 molecule
CDK6 cyclin-dependent kinase 6
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EDN1 endothelin 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPCAM epithelial cell adhesion molecule
FADS2 fatty acid desaturase 2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FDPS farnesyl diphosphate synthase
FILIP1L filamin A interacting protein 1-like
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HEPH hephaestin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
INSIG1 insulin induced gene 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
KLK5 kallikrein-related peptidase 5
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTB lymphotoxin beta (TNF superfamily, member 3)
MAN1A1 mannosidase, alpha, class 1A, member 1
MT1M metallothionein 1M
OSBPL10 oxysterol binding protein-like 10
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SYT1 synaptotagmin I
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ANXA1 annexin A1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CALR calreticulin
CHPT1 choline phosphotransferase 1
CTSB cathepsin B
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EMP1 epithelial membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ITGB1BP1 integrin beta 1 binding protein 1
ITM2A integral membrane protein 2A
MAP2K3 mitogen-activated protein kinase kinase 3
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
SPEN spen family transcriptional repressor
SPRR3 small proline-rich protein 3
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZBTB18 zinc finger and BTB domain containing 18
Funding