BRD-K54233340_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K54233340_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ANK2 ankyrin 2, neuronal
ARHGAP29 Rho GTPase activating protein 29
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNG2 cyclin G2
CD24 CD24 molecule
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIDO1 death inducer-obliterator 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPT dermatopontin
DUSP4 dual specificity phosphatase 4
ELOVL4 ELOVL fatty acid elongase 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
FAM129A family with sequence similarity 129, member A
FAM49A family with sequence similarity 49, member A
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GREM1 gremlin 1, DAN family BMP antagonist
HSPA13 heat shock protein 70kDa family, member 13
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL17RB interleukin 17 receptor B
IL1RN interleukin 1 receptor antagonist
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KLF10 Kruppel-like factor 10
LYZ lysozyme
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFC platelet derived growth factor C
PHGDH phosphoglycerate dehydrogenase
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RSRP1 arginine/serine-rich protein 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPON1 spondin 1, extracellular matrix protein
SSPN sarcospan
STC2 stanniocalcin 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMSB15A thymosin beta 15a
TOB1 transducer of ERBB2, 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UFM1 ubiquitin-fold modifier 1
WARS tryptophanyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ANKRD10 ankyrin repeat domain 10
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
CBR3 carbonyl reductase 3
CD58 CD58 molecule
CD70 CD70 molecule
CDC25B cell division cycle 25B
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP55 centrosomal protein 55kDa
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSC cathepsin C
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
EPHA3 EPH receptor A3
ETV1 ets variant 1
FAM216A family with sequence similarity 216, member A
FXYD5 FXYD domain containing ion transport regulator 5
GALE UDP-galactose-4-epimerase
GOLGA8A golgin A8 family, member A
HMGA2 high mobility group AT-hook 2
HOXC10 homeobox C10
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGSF3 immunoglobulin superfamily, member 3
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF14 kinesin family member 14
KPNB1 karyopherin (importin) beta 1
KRT7 keratin 7, type II
KYNU kynureninase
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LPXN leupaxin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
PMP22 peripheral myelin protein 22
PSIP1 PC4 and SFRS1 interacting protein 1
PURA purine-rich element binding protein A
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLPI secretory leukocyte peptidase inhibitor
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNX10 sorting nexin 10
TARBP1 TAR (HIV-1) RNA binding protein 1
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5
TNC tenascin C
TRAPPC12 trafficking protein particle complex 12
TRIP6 thyroid hormone receptor interactor 6
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
ZNF638 zinc finger protein 638
Funding