BRD-K54233340_Dorsomorphin dihydrochloride_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

376 genes differentially expressed following the BRD-K54233340_Dorsomorphin dihydrochloride_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ACPP acid phosphatase, prostate
ADIRF adipogenesis regulatory factor
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALCAM activated leukocyte cell adhesion molecule
ALDOB aldolase B, fructose-bisphosphate
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BHLHE40 basic helix-loop-helix family, member e40
BPI bactericidal/permeability-increasing protein
CA2 carbonic anhydrase II
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCK cholecystokinin
CCNL1 cyclin L1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
CNPY3 canopy FGF signaling regulator 3
COCH cochlin
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DPT dermatopontin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FASTKD5 FAST kinase domains 5
FGG fibrinogen gamma chain
FKBP1A FK506 binding protein 1A, 12kDa
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GREB1 growth regulation by estrogen in breast cancer 1
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFT57 intraflagellar transport 57
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
IRF8 interferon regulatory factor 8
ISL1 ISL LIM homeobox 1
KLF10 Kruppel-like factor 10
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LDB2 LIM domain binding 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS2 lectin, galactoside-binding, soluble, 2
LMO4 LIM domain only 4
LPL lipoprotein lipase
LTA4H leukotriene A4 hydrolase
LTF lactotransferrin
LY96 lymphocyte antigen 96
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MLF1 myeloid leukemia factor 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1G metallothionein 1G
MYOT myotilin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NRIP1 nuclear receptor interacting protein 1
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCLO piccolo presynaptic cytomatrix protein
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PITX1 paired-like homeodomain 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PRSS21 protease, serine, 21 (testisin)
PRSS8 protease, serine, 8
PRTN3 proteinase 3
PSENEN presenilin enhancer gamma secretase subunit
PTH2R parathyroid hormone 2 receptor
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RLN1 relaxin 1
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFRP1 secreted frizzled-related protein 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SST somatostatin
STC2 stanniocalcin 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WASF1 WAS protein family, member 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
AMIGO2 adhesion molecule with Ig-like domain 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ATP13A3 ATPase type 13A3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
BLM Bloom syndrome, RecQ helicase-like
BLMH bleomycin hydrolase
C16ORF45 chromosome 16 open reading frame 45
C1QTNF3 C1q and tumor necrosis factor related protein 3
C2CD2 C2 calcium-dependent domain containing 2
C2CD5 C2 calcium-dependent domain containing 5
CANT1 calcium activated nucleotidase 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COG2 component of oligomeric golgi complex 2
CPB1 carboxypeptidase B1 (tissue)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRTC3 CREB regulated transcription coactivator 3
CTPS1 CTP synthase 1
CXCL5 chemokine (C-X-C motif) ligand 5
DAPK1 death-associated protein kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIXDC1 DIX domain containing 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK10 dedicator of cytokinesis 10
DOCK9 dedicator of cytokinesis 9
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERMP1 endoplasmic reticulum metallopeptidase 1
ETV5 ets variant 5
EXPH5 exophilin 5
FAM57A family with sequence similarity 57, member A
FBXO21 F-box protein 21
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FNDC3B fibronectin type III domain containing 3B
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GLCE glucuronic acid epimerase
GPSM2 G-protein signaling modulator 2
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HMGA2 high mobility group AT-hook 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXA5 homeobox A5
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IL20RA interleukin 20 receptor, alpha
IL6R interleukin 6 receptor
IQGAP2 IQ motif containing GTPase activating protein 2
IRF2 interferon regulatory factor 2
IRF4 interferon regulatory factor 4
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIF2C kinesin family member 2C
KRT18 keratin 18, type I
KRT20 keratin 20, type I
LCMT2 leucine carboxyl methyltransferase 2
LEFTY1 left-right determination factor 1
LOC100272216 uncharacterized LOC100272216
LRP4 low density lipoprotein receptor-related protein 4
LRRC16A leucine rich repeat containing 16A
LRRC41 leucine rich repeat containing 41
LYPD3 LY6/PLAUR domain containing 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKSL1 MARCKS-like 1
MED13 mediator complex subunit 13
MMP3 matrix metallopeptidase 3
MRPS30 mitochondrial ribosomal protein S30
MRPS35 mitochondrial ribosomal protein S35
MTCL1 microtubule crosslinking factor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NAE1 NEDD8 activating enzyme E1 subunit 1
NOTCH1 notch 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PFKP phosphofructokinase, platelet
PGRMC2 progesterone receptor membrane component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP prolactin-induced protein
PLS3 plastin 3
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PSD3 pleckstrin and Sec7 domain containing 3
RECQL RecQ helicase-like
RIN2 Ras and Rab interactor 2
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A11 S100 calcium binding protein A11
SACS sacsin molecular chaperone
SCGB2A2 secretoglobin, family 2A, member 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SRSF2 serine/arginine-rich splicing factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNJ2 synaptojanin 2
TBC1D31 TBC1 domain family, member 31
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TJP2 tight junction protein 2
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIL TLR4 interactor with leucine-rich repeats
TRPS1 trichorhinophalangeal syndrome I
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UMPS uridine monophosphate synthetase
VAV3 vav 3 guanine nucleotide exchange factor
WNT5A wingless-type MMTV integration site family, member 5A
ZNF451 zinc finger protein 451
Funding