BRD-K54256913_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K54256913_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPE centromere protein E, 312kDa
COL9A2 collagen, type IX, alpha 2
DDIT4 DNA-damage-inducible transcript 4
GSN gelsolin
HCP5 HLA complex P5 (non-protein coding)
HLA-F major histocompatibility complex, class I, F
HMG20B high mobility group 20B
HOOK2 hook microtubule-tethering protein 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER3 immediate early response 3
ITGA6 integrin, alpha 6
KDM4B lysine (K)-specific demethylase 4B
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LUC7L3 LUC7-like 3 (S. cerevisiae)
MXD4 MAX dimerization protein 4
MZT2A mitotic spindle organizing protein 2A
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSRC1 proline/serine-rich coiled-coil 1
RAP1GAP RAP1 GTPase activating protein
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SESN1 sestrin 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRRM2 serine/arginine repetitive matrix 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
ZMAT3 zinc finger, matrin-type 3
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A2 collagen, type V, alpha 2
CYCS cytochrome c, somatic
DCN decorin
DOK5 docking protein 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HSPA2 heat shock 70kDa protein 2
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
ITM2C integral membrane protein 2C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLIN2 perilipin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PTGIS prostaglandin I2 (prostacyclin) synthase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN2 regulator of calcineurin 2
RFC4 replication factor C (activator 1) 4, 37kDa
RGS4 regulator of G-protein signaling 4
RPA3 replication protein A3, 14kDa
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLBP stem-loop binding protein
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
WBP5 WW domain binding protein 5
Funding