BRD-K54256913_MK-1775_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K54256913_MK-1775_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AMIGO2 adhesion molecule with Ig-like domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CBS cystathionine-beta-synthase
CEMIP cell migration inducing protein, hyaluronan binding
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSTA cystatin A (stefin A)
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DPYD dihydropyrimidine dehydrogenase
F3 coagulation factor III (thromboplastin, tissue factor)
FXYD5 FXYD domain containing ion transport regulator 5
GPATCH8 G patch domain containing 8
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KLF5 Kruppel-like factor 5 (intestinal)
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR3 phospholipid scramblase 3
PSAT1 phosphoserine aminotransferase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
SARS seryl-tRNA synthetase
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TRIM16 tripartite motif containing 16
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ASPN asporin
BCAP31 B-cell receptor-associated protein 31
C3ORF14 chromosome 3 open reading frame 14
CCND2 cyclin D2
CLU clusterin
CREB1 cAMP responsive element binding protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FASN fatty acid synthase
FGFR1 fibroblast growth factor receptor 1
GLIPR1 GLI pathogenesis-related 1
HELLS helicase, lymphoid-specific
HMGB3 high mobility group box 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LTB lymphotoxin beta (TNF superfamily, member 3)
MXRA7 matrix-remodelling associated 7
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NRIP1 nuclear receptor interacting protein 1
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGRMC1 progesterone receptor membrane component 1
PON2 paraoxonase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBM47 RNA binding motif protein 47
RPS11 ribosomal protein S11
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TACC1 transforming, acidic coiled-coil containing protein 1
TTC39A tetratricopeptide repeat domain 39A
VTCN1 V-set domain containing T cell activation inhibitor 1
Funding