BRD-K54256913_MK-1775_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K54256913_MK-1775_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCR4 chemokine (C-X-C motif) receptor 4
DDB2 damage-specific DNA binding protein 2, 48kDa
DSG2 desmoglein 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EGR1 early growth response 1
EGR2 early growth response 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAS Fas cell surface death receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
IFI6 interferon, alpha-inducible protein 6
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
LPXN leupaxin
LRRC32 leucine rich repeat containing 32
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
MMP9 matrix metallopeptidase 9
MRPL19 mitochondrial ribosomal protein L19
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PSAT1 phosphoserine aminotransferase 1
RGS1 regulator of G-protein signaling 1
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SECISBP2L SECIS binding protein 2-like
SESN1 sestrin 1
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPEN spen family transcriptional repressor
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TP53I3 tumor protein p53 inducible protein 3
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
APLP2 amyloid beta (A4) precursor-like protein 2
APOA2 apolipoprotein A-II
CALR calreticulin
CCNF cyclin F
CDC25A cell division cycle 25A
COL1A2 collagen, type I, alpha 2
DLK1 delta-like 1 homolog (Drosophila)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA3 EPH receptor A3
FGG fibrinogen gamma chain
FLNA filamin A, alpha
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GATA3 GATA binding protein 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KCTD12 potassium channel tetramerization domain containing 12
LIN28A lin-28 homolog A (C. elegans)
MATN2 matrilin 2
MCM3 minichromosome maintenance complex component 3
MGP matrix Gla protein
MXRA5 matrix-remodelling associated 5
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NMU neuromedin U
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PRKD3 protein kinase D3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORBS3 sorbin and SH3 domain containing 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM9SF3 transmembrane 9 superfamily member 3
TMEM194A transmembrane protein 194A
TUBB2A tubulin, beta 2A class IIa
WDTC1 WD and tetratricopeptide repeats 1
Funding