BRD-K54256913_MK-1775_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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68 genes differentially expressed following the BRD-K54256913_MK-1775_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTA1 actin, alpha 1, skeletal muscle
ANK2 ankyrin 2, neuronal
AQP1 aquaporin 1 (Colton blood group)
ARG2 arginase 2
ATP13A3 ATPase type 13A3
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNA1 cyclin A1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CKM creatine kinase, muscle
CLIC4 chloride intracellular channel 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DES desmin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC4 exosome component 4
FBLN1 fibulin 1
GDF15 growth differentiation factor 15
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HSPB8 heat shock 22kDa protein 8
IL6ST interleukin 6 signal transducer
KLHL41 kelch-like family member 41
LMO4 LIM domain only 4
LTF lactotransferrin
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MECOM MDS1 and EVI1 complex locus
MSMB microseminoprotein, beta-
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NEB nebulin
NRN1 neuritin 1
NUAK1 NUAK family, SNF1-like kinase, 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RAD21 RAD21 homolog (S. pombe)
S100A6 S100 calcium binding protein A6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLN sarcolipin
STC1 stanniocalcin 1
TBC1D31 TBC1 domain family, member 31
TFPI2 tissue factor pathway inhibitor 2
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TSPYL5 TSPY-like 5
TTN titin
TWF1 twinfilin actin binding protein 1
TXNIP thioredoxin interacting protein
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
C2CD5 C2 calcium-dependent domain containing 5
CD59 CD59 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
DACH1 dachshund family transcription factor 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
GUSBP11 glucuronidase, beta pseudogene 11
MYLK myosin light chain kinase
MYO5C myosin VC
NSG1 neuron specific gene family member 1
RGS4 regulator of G-protein signaling 4
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TM4SF4 transmembrane 4 L six family member 4
XIST X inactive specific transcript (non-protein coding)