BRD-K54330070_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K54330070_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ASS1 argininosuccinate synthase 1
CCND2 cyclin D2
CLIP3 CAP-GLY domain containing linker protein 3
COLEC12 collectin sub-family member 12
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
GRHPR glyoxylate reductase/hydroxypyruvate reductase
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
IL11RA interleukin 11 receptor, alpha
LDOC1 leucine zipper, down-regulated in cancer 1
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MYB v-myb avian myeloblastosis viral oncogene homolog
NREP neuronal regeneration related protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
SMYD3 SET and MYND domain containing 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TP53 tumor protein p53
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ARG1 arginase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BAG3 BCL2-associated athanogene 3
CAV2 caveolin 2
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL4A2 collagen, type IV, alpha 2
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPHA2 EPH receptor A2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
ITGA6 integrin, alpha 6
KRT6B keratin 6B, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLPH melanophilin
MOK MOK protein kinase
NET1 neuroepithelial cell transforming 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB2 tribbles pseudokinase 2
UBE2C ubiquitin-conjugating enzyme E2C
ZNF586 zinc finger protein 586
Funding