BRD-K54606188_(+)-JQ1_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

210 genes differentially expressed following the BRD-K54606188_(+)-JQ1_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADI1 acireductone dioxygenase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANKRD11 ankyrin repeat domain 11
ANKRD36B ankyrin repeat domain 36B
AREG amphiregulin
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BPTF bromodomain PHD finger transcription factor
BTG1 B-cell translocation gene 1, anti-proliferative
C9ORF16 chromosome 9 open reading frame 16
CA2 carbonic anhydrase II
CALCRL calcitonin receptor-like
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CIRBP cold inducible RNA binding protein
CLCA1 chloride channel accessory 1
CLNS1A chloride channel, nucleotide-sensitive, 1A
CPA3 carboxypeptidase A3 (mast cell)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXADR coxsackie virus and adenovirus receptor
CXORF57 chromosome X open reading frame 57
DCAF16 DDB1 and CUL4 associated factor 16
DSP desmoplakin
EMP2 epithelial membrane protein 2
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGL1 fibrinogen-like 1
GAGE3 G antigen 3
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HDAC1 histone deacetylase 1
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HOXA10 homeobox A10
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IL13RA2 interleukin 13 receptor, alpha 2
INPP5F inositol polyphosphate-5-phosphatase F
ISYNA1 inositol-3-phosphate synthase 1
JAG2 jagged 2
KIAA1598
KLHL24 kelch-like family member 24
LOC100272216 uncharacterized LOC100272216
LTBP1 latent transforming growth factor beta binding protein 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MUC2 mucin 2, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
ORM1 orosomucoid 1
OSR2 odd-skipped related transciption factor 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PGAP1 post-GPI attachment to proteins 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G16 phospholipase A2, group XVI
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PURA purine-rich element binding protein A
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SPINK4 serine peptidase inhibitor, Kazal type 4
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TFRC transferrin receptor
THBD thrombomodulin
THBS2 thrombospondin 2
TMEM30B transmembrane protein 30B
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TXNRD1 thioredoxin reductase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZG16 zymogen granule protein 16
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANPEP alanyl (membrane) aminopeptidase
ARF1 ADP-ribosylation factor 1
AXL AXL receptor tyrosine kinase
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C1QB complement component 1, q subcomponent, B chain
C6ORF62 chromosome 6 open reading frame 62
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD59 CD59 molecule, complement regulatory protein
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CST1 cystatin SN
CST7 cystatin F (leukocystatin)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTL1 cytokine-like 1
DCLK1 doublecortin-like kinase 1
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GTF3A general transcription factor IIIA
HBB hemoglobin, beta
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
JMJD6 jumonji domain containing 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMAN1 lectin, mannose-binding, 1
LOX lysyl oxidase
LTF lactotransferrin
MICALL1 MICAL-like 1
MOK MOK protein kinase
MYL9 myosin, light chain 9, regulatory
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NREP neuronal regeneration related protein
ODAM odontogenic, ameloblast asssociated
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDGFC platelet derived growth factor C
PEA15 phosphoprotein enriched in astrocytes 15
PLAT plasminogen activator, tissue
PLTP phospholipid transfer protein
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
REEP5 receptor accessory protein 5
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SFRP1 secreted frizzled-related protein 1
SLAMF8 SLAM family member 8
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
TAGLN2 transgelin 2
TARP TCR gamma alternate reading frame protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TRIB2 tribbles pseudokinase 2
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1
XBP1 X-box binding protein 1
XPO7 exportin 7
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZBTB38 zinc finger and BTB domain containing 38
Funding