BRD-K54606188_(+)-JQ1_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-K54606188_(+)-JQ1_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACACB acetyl-CoA carboxylase beta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD11 ankyrin repeat domain 11
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
BRD4 bromodomain containing 4
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPM carboxypeptidase M
CPT1A carnitine palmitoyltransferase 1A (liver)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CUX1 cut-like homeobox 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DARS aspartyl-tRNA synthetase
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DUSP6 dual specificity phosphatase 6
EI24 etoposide induced 2.4
ENAH enabled homolog (Drosophila)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FOXO1 forkhead box O1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAGE3 G antigen 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAL histidine ammonia-lyase
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HOOK2 hook microtubule-tethering protein 2
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISYNA1 inositol-3-phosphate synthase 1
KIF2C kinesin family member 2C
LAGE3 L antigen family, member 3
LINC00341 long intergenic non-protein coding RNA 341
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MEF2C myocyte enhancer factor 2C
MID1IP1 MID1 interacting protein 1
MKL2 MKL/myocardin-like 2
MLXIP MLX interacting protein
MYH10 myosin, heavy chain 10, non-muscle
MYO6 myosin VI
NQO1 NAD(P)H dehydrogenase, quinone 1
NXN nucleoredoxin
ORM1 orosomucoid 1
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PHF20 PHD finger protein 20
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLIN2 perilipin 2
PNKP polynucleotide kinase 3'-phosphatase
PRAF2 PRA1 domain family, member 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PSIP1 PC4 and SFRS1 interacting protein 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBP4 retinol binding protein 4, plasma
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SON SON DNA binding protein
SQRDL sulfide quinone reductase-like (yeast)
STXBP1 syntaxin binding protein 1
TFRC transferrin receptor
THOC2 THO complex 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TOB1 transducer of ERBB2, 1
TSPAN13 tetraspanin 13
TXNRD1 thioredoxin reductase 1
USP9X ubiquitin specific peptidase 9, X-linked
WFS1 Wolfram syndrome 1 (wolframin)
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADGRE5 adhesion G protein-coupled receptor E5
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOD apolipoprotein D
APOL3 apolipoprotein L, 3
AQP3 aquaporin 3 (Gill blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE41 basic helix-loop-helix family, member e41
C1ORF116 chromosome 1 open reading frame 116
CALB1 calbindin 1, 28kDa
CAST calpastatin
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CD38 CD38 molecule
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL8A2 collagen, type VIII, alpha 2
COPS7A COP9 signalosome subunit 7A
CRYZ crystallin, zeta (quinone reductase)
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOCK10 dedicator of cytokinesis 10
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGF1 fibroblast growth factor 1 (acidic)
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
ICAM1 intercellular adhesion molecule 1
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL15 interleukin 15
IL32 interleukin 32
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFSD1 major facilitator superfamily domain containing 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MYL9 myosin, light chain 9, regulatory
NBN nibrin
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP3 nuclear receptor interacting protein 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDLIM5 PDZ and LIM domain 5
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKD3 protein kinase D3
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOBTB3 Rho-related BTB domain containing 3
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SUB1 SUB1 homolog (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TARP TCR gamma alternate reading frame protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TMPRSS11E transmembrane protease, serine 11E
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TRAF1 TNF receptor-associated factor 1
TRAPPC3 trafficking protein particle complex 3
TRIP6 thyroid hormone receptor interactor 6
TSPO translocator protein (18kDa)
VCAM1 vascular cell adhesion molecule 1
WARS tryptophanyl-tRNA synthetase
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
XPO7 exportin 7
ZBTB20 zinc finger and BTB domain containing 20
ZBTB38 zinc finger and BTB domain containing 38
Funding