BRD-K54606188_(+)-JQ1_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K54606188_(+)-JQ1_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ALDOA aldolase A, fructose-bisphosphate
AREG amphiregulin
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BGN biglycan
CALCA calcitonin-related polypeptide alpha
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDV3 CDV3 homolog (mouse)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CEMIP cell migration inducing protein, hyaluronan binding
CIRBP cold inducible RNA binding protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUSP14 dual specificity phosphatase 14
FADS3 fatty acid desaturase 3
FAM46A family with sequence similarity 46, member A
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI30 interferon, gamma-inducible protein 30
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
INSR insulin receptor
IRF7 interferon regulatory factor 7
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0226 KIAA0226
KIAA1033 KIAA1033
KRT16 keratin 16, type I
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LGMN legumain
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MXRA7 matrix-remodelling associated 7
NBPF10 neuroblastoma breakpoint family, member 10
NDNF neuron-derived neurotrophic factor
NEFH neurofilament, heavy polypeptide
NR4A3 nuclear receptor subfamily 4, group A, member 3
ORM1 orosomucoid 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAX5 paired box 5
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
QPCT glutaminyl-peptide cyclotransferase
RAB21 RAB21, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCOR1 REST corepressor 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGC Ras-related GTP binding C
SAT1 spermidine/spermine N1-acetyltransferase 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC16A6 solute carrier family 16, member 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SNN stannin
SPATA2L spermatogenesis associated 2-like
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
STOM stomatin
STXBP1 syntaxin binding protein 1
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TBX3 T-box 3
TOB2 transducer of ERBB2, 2
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TPST2 tyrosylprotein sulfotransferase 2
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
VCL vinculin
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BAD BCL2-associated agonist of cell death
BCHE butyrylcholinesterase
CBR3 carbonyl reductase 3
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CFH complement factor H
CFI complement factor I
CHL1 cell adhesion molecule L1-like
CLEC2B C-type lectin domain family 2, member B
COPS7A COP9 signalosome subunit 7A
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPT dermatopontin
ECI2 enoyl-CoA delta isomerase 2
EMP1 epithelial membrane protein 1
EPN2 epsin 2
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FANCG Fanconi anemia, complementation group G
FOXM1 forkhead box M1
GGCT gamma-glutamylcyclotransferase
GRIA2 glutamate receptor, ionotropic, AMPA 2
GYPC glycophorin C (Gerbich blood group)
HMGA2 high mobility group AT-hook 2
HSPB1 heat shock 27kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
LMNB1 lamin B1
MANSC1 MANSC domain containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MEIS2 Meis homeobox 2
MELK maternal embryonic leucine zipper kinase
MFAP2 microfibrillar-associated protein 2
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MYOF myoferlin
NAV3 neuron navigator 3
NET1 neuroepithelial cell transforming 1
NMI N-myc (and STAT) interactor
NRP1 neuropilin 1
NUAK1 NUAK family, SNF1-like kinase, 1
PDLIM1 PDZ and LIM domain 1
PDLIM3 PDZ and LIM domain 3
PIP prolactin-induced protein
PODXL podocalyxin-like
PRDX2 peroxiredoxin 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RAD23B RAD23 homolog B (S. cerevisiae)
S100A4 S100 calcium binding protein A4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX17 SRY (sex determining region Y)-box 17
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THYN1 thymocyte nuclear protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TRIM14 tripartite motif containing 14
VGLL4 vestigial-like family member 4
WT1 Wilms tumor 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZHX2 zinc fingers and homeoboxes 2
ZNF91 zinc finger protein 91
ZW10 zw10 kinetochore protein
Funding