BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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66 genes differentially expressed following the BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AEBP1 AE binding protein 1
BCHE butyrylcholinesterase
CADM1 cell adhesion molecule 1
CDC42 cell division cycle 42
CPB1 carboxypeptidase B1 (tissue)
DIDO1 death inducer-obliterator 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
EZR ezrin
FGFR1 fibroblast growth factor receptor 1
GPNMB glycoprotein (transmembrane) nmb
GSTA1 glutathione S-transferase alpha 1
LRRC15 leucine rich repeat containing 15
LUM lumican
MSMB microseminoprotein, beta-
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOV nephroblastoma overexpressed
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLAU plasminogen activator, urokinase
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP1 ubiquitin specific peptidase 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
C2CD5 C2 calcium-dependent domain containing 5
CAPRIN2 caprin family member 2
CCNB1 cyclin B1
CCND2 cyclin D2
CCNF cyclin F
CDC25B cell division cycle 25B
CTSE cathepsin E
DST dystonin
EGFR epidermal growth factor receptor
GOLGA8A golgin A8 family, member A
GSAP gamma-secretase activating protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
JADE2 jade family PHD finger 2
LOC100272216 uncharacterized LOC100272216
MBNL2 muscleblind-like splicing regulator 2
MYBPC1 myosin binding protein C, slow type
PBX3 pre-B-cell leukemia homeobox 3
PKP2 plakophilin 2
PPARG peroxisome proliferator-activated receptor gamma
PTEN phosphatase and tensin homolog
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPG11 spastic paraplegia 11 (autosomal recessive)
TBC1D31 TBC1 domain family, member 31
TCERG1 transcription elongation regulator 1
TMEM2 transmembrane protein 2
TOX3 TOX high mobility group box family member 3
TPST2 tyrosylprotein sulfotransferase 2
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE3C ubiquitin protein ligase E3C
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
YBX3 Y box binding protein 3