BRD-K54997624_BYL719_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K54997624_BYL719_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN3 claudin 3
CXCL14 chemokine (C-X-C motif) ligand 14
EFNA1 ephrin-A1
ELOVL2 ELOVL fatty acid elongase 2
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FOXO4 forkhead box O4
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HSPA2 heat shock 70kDa protein 2
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP5 insulin-like growth factor binding protein 5
KDM3A lysine (K)-specific demethylase 3A
MARCKSL1 MARCKS-like 1
MXI1 MAX interactor 1, dimerization protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLIN2 perilipin 2
RBL2 retinoblastoma-like 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SKAP2 src kinase associated phosphoprotein 2
SLC38A2 solute carrier family 38, member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN31 tetraspanin 31
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
AK1 adenylate kinase 1
CLU clusterin
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
IFRD2 interferon-related developmental regulator 2
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NSFL1C NSFL1 (p97) cofactor (p47)
OGFRL1 opioid growth factor receptor-like 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PGC progastricsin (pepsinogen C)
PLXNA2 plexin A2
PXDN peroxidasin
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RRBP1 ribosome binding protein 1
SPP1 secreted phosphoprotein 1
TFRC transferrin receptor
TLR4 toll-like receptor 4
Funding