BRD-K55187425_ON-01910_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K55187425_ON-01910_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
CCL2 chemokine (C-C motif) ligand 2
CD8A CD8a molecule
CST7 cystatin F (leukocystatin)
GADD45A growth arrest and DNA-damage-inducible, alpha
GLIPR1 GLI pathogenesis-related 1
GSN gelsolin
HBEGF heparin-binding EGF-like growth factor
IL32 interleukin 32
IL7R interleukin 7 receptor
ITGA6 integrin, alpha 6
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LAMC2 laminin, gamma 2
MECOM MDS1 and EVI1 complex locus
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
C5 complement component 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDK1 cyclin-dependent kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ETV1 ets variant 1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GLRX glutaredoxin (thioltransferase)
H1FX H1 histone family, member X
HMGB2 high mobility group box 2
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
MAP2K6 mitogen-activated protein kinase kinase 6
MDFIC MyoD family inhibitor domain containing
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOTCH3 notch 3
NUSAP1 nucleolar and spindle associated protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PGD phosphogluconate dehydrogenase
RAP1GAP RAP1 GTPase activating protein
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
SNAP25 synaptosomal-associated protein, 25kDa
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TMEM100 transmembrane protein 100
TOP2A topoisomerase (DNA) II alpha 170kDa
TSKU tsukushi, small leucine rich proteoglycan
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
Funding