BRD-K55187425_ON-01910_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K55187425_ON-01910_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AURKA aurora kinase A
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CCND2 cyclin D2
CHGB chromogranin B
CHIC2 cysteine-rich hydrophobic domain 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCR4 chemokine (C-X-C motif) receptor 4
DLC1 DLC1 Rho GTPase activating protein
DMD dystrophin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
EIF5A eukaryotic translation initiation factor 5A
FERMT2 fermitin family member 2
FNBP1 formin binding protein 1
GAL galanin/GMAP prepropeptide
GLIPR1 GLI pathogenesis-related 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA8 heat shock 70kDa protein 8
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KIAA0226L KIAA0226-like
KIAA0368 KIAA0368
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LARP1 La ribonucleoprotein domain family, member 1
LIMS1 LIM and senescent cell antigen-like domains 1
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MFSD12 major facilitator superfamily domain containing 12
MT1M metallothionein 1M
NEFL neurofilament, light polypeptide
NNMT nicotinamide N-methyltransferase
NTS neurotensin
NUTF2 nuclear transport factor 2
OXSR1 oxidative stress responsive 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
RFTN1 raftlin, lipid raft linker 1
RREB1 ras responsive element binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAP25 synaptosomal-associated protein, 25kDa
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SSR1 signal sequence receptor, alpha
TCF3 transcription factor 3
TGFB1 transforming growth factor, beta 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
WNT5B wingless-type MMTV integration site family, member 5B

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADD3 adducin 3 (gamma)
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANXA9 annexin A9
APLP2 amyloid beta (A4) precursor-like protein 2
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
CCNE2 cyclin E2
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CDK1 cyclin-dependent kinase 1
CFI complement factor I
COL3A1 collagen, type III, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
DEFB1 defensin, beta 1
DPP4 dipeptidyl-peptidase 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ETV1 ets variant 1
FBLN1 fibulin 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD3 FXYD domain containing ion transport regulator 3
GAS7 growth arrest-specific 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTT1 glutathione S-transferase theta 1
HBB hemoglobin, beta
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
MLPH melanophilin
MUC4 mucin 4, cell surface associated
MX2 MX dynamin-like GTPase 2
MXRA5 matrix-remodelling associated 5
MYRF myelin regulatory factor
NID2 nidogen 2 (osteonidogen)
OLFML2A olfactomedin-like 2A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCNA proliferating cell nuclear antigen
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRKCD protein kinase C, delta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAD9A RAD9 homolog A (S. pombe)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
S100A10 S100 calcium binding protein A10
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN1 tetraspanin 1
TWF2 twinfilin actin binding protein 2
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
ZFPM2 zinc finger protein, FOG family member 2
Funding