BRD-K55722623_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K55722623_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
CALML3 calmodulin-like 3
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
DHRS9 dehydrogenase/reductase (SDR family) member 9
EDN3 endothelin 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KCTD5 potassium channel tetramerization domain containing 5
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS2 lectin, galactoside-binding, soluble, 2
LPAR1 lysophosphatidic acid receptor 1
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
POPDC3 popeye domain containing 3
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RHOC ras homolog family member C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFTPB surfactant protein B
SHOX2 short stature homeobox 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TNC tenascin C
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ANOS1 anosmin 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
COL10A1 collagen, type X, alpha 1
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CYBA cytochrome b-245, alpha polypeptide
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
KRT19 keratin 19, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
NDRG2 NDRG family member 2
NREP neuronal regeneration related protein
PEBP1 phosphatidylethanolamine binding protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PNMAL1 paraneoplastic Ma antigen family-like 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PURA purine-rich element binding protein A
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOBTB3 Rho-related BTB domain containing 3
RPL37A ribosomal protein L37a
SAV1 salvador family WW domain containing protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SRSF6 serine/arginine-rich splicing factor 6
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSPYL5 TSPY-like 5
TSTA3 tissue specific transplantation antigen P35B
UBE2E3 ubiquitin-conjugating enzyme E2E 3
Funding