BRD-K56196992_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K56196992_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AGA aspartylglucosaminidase
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
CD200 CD200 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CIRBP cold inducible RNA binding protein
CLEC3B C-type lectin domain family 3, member B
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EPS8 epidermal growth factor receptor pathway substrate 8
FOSB FBJ murine osteosarcoma viral oncogene homolog B
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
LDB2 LIM domain binding 2
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MCAM melanoma cell adhesion molecule
MYH11 myosin, heavy chain 11, smooth muscle
MYO1B myosin IB
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCP4 Purkinje cell protein 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SMAD3 SMAD family member 3
SNN stannin
TEK TEK tyrosine kinase, endothelial
TES testin LIM domain protein
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TSPAN7 tetraspanin 7
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
CCDC86 coiled-coil domain containing 86
CDC25A cell division cycle 25A
CXCL9 chemokine (C-X-C motif) ligand 9
EXOSC4 exosome component 4
HMGA2 high mobility group AT-hook 2
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
LTF lactotransferrin
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10