BRD-K56301217_ABT-737_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K56301217_ABT-737_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRG2 adhesion G protein-coupled receptor G2
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BANK1 B-cell scaffold protein with ankyrin repeats 1
BPHL biphenyl hydrolase-like (serine hydrolase)
CBS cystathionine-beta-synthase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLGN calmegin
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
DPEP1 dipeptidase 1 (renal)
EHF ets homologous factor
EPHA3 EPH receptor A3
GRN granulin
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK2 hook microtubule-tethering protein 2
JMJD6 jumonji domain containing 6
KIAA0226L KIAA0226-like
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTN pleiotrophin
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPON2 spondin 2, extracellular matrix protein
TSPAN8 tetraspanin 8
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASCL1 achaete-scute family bHLH transcription factor 1
ATXN1 ataxin 1
CAB39 calcium binding protein 39
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
COL4A6 collagen, type IV, alpha 6
COPS7A COP9 signalosome subunit 7A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
HSPA1A heat shock 70kDa protein 1A
ISOC1 isochorismatase domain containing 1
LMO4 LIM domain only 4
LPL lipoprotein lipase
MEIS2 Meis homeobox 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFC platelet derived growth factor C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RPS4Y1 ribosomal protein S4, Y-linked 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SRSF6 serine/arginine-rich splicing factor 6
TRIM22 tripartite motif containing 22
Funding