BRD-K56343971_vemurafenib_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K56343971_vemurafenib_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
AHNAK2 AHNAK nucleoprotein 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
CADM1 cell adhesion molecule 1
CCDC92 coiled-coil domain containing 92
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CST3 cystatin C
CTSO cathepsin O
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
HLA-DMA major histocompatibility complex, class II, DM alpha
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
MECOM MDS1 and EVI1 complex locus
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
ORAI3 ORAI calcium release-activated calcium modulator 3
PAM peptidylglycine alpha-amidating monooxygenase
PBX1 pre-B-cell leukemia homeobox 1
PDGFD platelet derived growth factor D
PIR pirin (iron-binding nuclear protein)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPAP2A phosphatidic acid phosphatase type 2A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCRG1 stimulator of chondrogenesis 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX2 SRY (sex determining region Y)-box 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSB2 tryptase beta 2 (gene/pseudogene)
VDAC1 voltage-dependent anion channel 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ANO1 anoctamin 1, calcium activated chloride channel
CCND1 cyclin D1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CENPU centromere protein U
COL4A2 collagen, type IV, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAL histidine ammonia-lyase
HES1 hes family bHLH transcription factor 1
HOXB6 homeobox B6
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KIAA1033 KIAA1033
KLF10 Kruppel-like factor 10
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBL1 neuroblastoma 1, DAN family BMP antagonist
NOP56 NOP56 ribonucleoprotein
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RRM2 ribonucleotide reductase M2
SOX11 SRY (sex determining region Y)-box 11
STX1A syntaxin 1A (brain)
TCL1A T-cell leukemia/lymphoma 1A
TGM2 transglutaminase 2
TMEM2 transmembrane protein 2
UFM1 ubiquitin-fold modifier 1
ZBTB18 zinc finger and BTB domain containing 18
Funding