BRD-K56343971_vemurafenib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K56343971_vemurafenib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACP5 acid phosphatase 5, tartrate resistant
ADGRG6 adhesion G protein-coupled receptor G6
AKR1C1 aldo-keto reductase family 1, member C1
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCHE butyrylcholinesterase
CCL5 chemokine (C-C motif) ligand 5
CD8A CD8a molecule
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CTSH cathepsin H
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FBP1 fructose-1,6-bisphosphatase 1
FOLR1 folate receptor 1 (adult)
GAGE3 G antigen 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
IFI27 interferon, alpha-inducible protein 27
IGHM immunoglobulin heavy constant mu
KRT13 keratin 13, type I
KRT23 keratin 23, type I
KRT4 keratin 4, type II
KRT7 keratin 7, type II
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MAST4 microtubule associated serine/threonine kinase family member 4
MGLL monoglyceride lipase
MLPH melanophilin
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PTER phosphotriesterase related
RABGAP1L RAB GTPase activating protein 1-like
RBP4 retinol binding protein 4, plasma
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLAMF7 SLAM family member 7
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
TF transferrin
THBS1 thrombospondin 1
TNPO1 transportin 1
TRA2A transformer 2 alpha homolog (Drosophila)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VNN1 vanin 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CDC20 cell division cycle 20
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL8 chemokine (C-X-C motif) ligand 8
E2F2 E2F transcription factor 2
EMP3 epithelial membrane protein 3
FABP7 fatty acid binding protein 7, brain
IDI1 isopentenyl-diphosphate delta isomerase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP5 lysosomal-associated membrane protein family, member 5
LMO2 LIM domain only 2 (rhombotin-like 1)
MSX1 msh homeobox 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDLIM5 PDZ and LIM domain 5
PPID peptidylprolyl isomerase D
PRPF4 pre-mRNA processing factor 4
PSPH phosphoserine phosphatase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RSL1D1 ribosomal L1 domain containing 1
S100A10 S100 calcium binding protein A10
SFRP1 secreted frizzled-related protein 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
ZNF430 zinc finger protein 430
Funding