BRD-K56343971_vemurafenib_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K56343971_vemurafenib_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANO10 anoctamin 10
ANXA4 annexin A4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP9A ATPase, class II, type 9A
AUH AU RNA binding protein/enoyl-CoA hydratase
BBS1 Bardet-Biedl syndrome 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CALCOCO1 calcium binding and coiled-coil domain 1
CAT catalase
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES2 carboxylesterase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
CRYL1 crystallin, lambda 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
GOLPH3L golgi phosphoprotein 3-like
GPC4 glypican 4
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSN gelsolin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI6 interferon, alpha-inducible protein 6
IGBP1 immunoglobulin (CD79A) binding protein 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
LY75 lymphocyte antigen 75
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MECOM MDS1 and EVI1 complex locus
MKRN1 makorin ring finger protein 1
MVP major vault protein
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NMRK1 nicotinamide riboside kinase 1
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB4 phospholipase C, beta 4
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROS1 protein S (alpha)
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRK protein tyrosine phosphatase, receptor type, K
RAB13 RAB13, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RBM47 RNA binding motif protein 47
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYF2 SYF2 pre-mRNA-splicing factor
TMEM30B transmembrane protein 30B
TMPRSS3 transmembrane protease, serine 3
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
TTC39A tetratricopeptide repeat domain 39A
TUSC3 tumor suppressor candidate 3
VAT1 vesicle amine transport 1
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRM1 adhesion regulating molecule 1
ANKRD10 ankyrin repeat domain 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BOP1 block of proliferation 1
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCNB1 cyclin B1
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKLF chemokine-like factor
COL15A1 collagen, type XV, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DBF4 DBF4 zinc finger
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FAM216A family with sequence similarity 216, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
KLHL7 kelch-like family member 7
LOXL1 lysyl oxidase-like 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDC1 NDC1 transmembrane nucleoporin
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAX5 paired box 5
PBK PDZ binding kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRMT1 protein arginine methyltransferase 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
THBS1 thrombospondin 1
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1
XIST X inactive specific transcript (non-protein coding)
Funding