BRD-K56343971_vemurafenib_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K56343971_vemurafenib_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AMDHD2 amidohydrolase domain containing 2
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
DDIT4 DNA-damage-inducible transcript 4
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
IARS isoleucyl-tRNA synthetase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKV4-1 immunoglobulin kappa variable 4-1
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MUC16 mucin 16, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PSAT1 phosphoserine aminotransferase 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PXDN peroxidasin
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK4 serine peptidase inhibitor, Kazal type 4
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
TMEM110 transmembrane protein 110
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TUSC3 tumor suppressor candidate 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ARL4C ADP-ribosylation factor-like 4C
ATF5 activating transcription factor 5
CDC25A cell division cycle 25A
CHIC2 cysteine-rich hydrophobic domain 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EREG epiregulin
FASTKD5 FAST kinase domains 5
GLIPR1 GLI pathogenesis-related 1
GPM6A glycoprotein M6A
GSN gelsolin
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
KCTD5 potassium channel tetramerization domain containing 5
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
LGALS3 lectin, galactoside-binding, soluble, 3
MYLK myosin light chain kinase
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PLIN2 perilipin 2
PRKCA protein kinase C, alpha
RALGDS ral guanine nucleotide dissociation stimulator
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SPEN spen family transcriptional repressor
XIST X inactive specific transcript (non-protein coding)
Funding