BRD-K56411643_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K56411643_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CLEC2B C-type lectin domain family 2, member B
CPM carboxypeptidase M
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ENO1 enolase 1, (alpha)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FAM69A family with sequence similarity 69, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGN osteoglycin
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PXDN peroxidasin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
SFRP4 secreted frizzled-related protein 4
STC1 stanniocalcin 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ATXN1 ataxin 1
AURKA aurora kinase A
B3GNT1
CALU calumenin
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CIRBP cold inducible RNA binding protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
EREG epiregulin
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
JADE1 jade family PHD finger 1
KRT7 keratin 7, type II
LGALS3 lectin, galactoside-binding, soluble, 3
MAGED1 melanoma antigen family D1
NPY neuropeptide Y
PLK1 polo-like kinase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRSS23 protease, serine, 23
SELT selenoprotein T
SRP54 signal recognition particle 54kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM9SF2 transmembrane 9 superfamily member 2
TMEM2 transmembrane protein 2
TNC tenascin C
TRAPPC4 trafficking protein particle complex 4