BRD-K56653679_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K56653679_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
BEX4 brain expressed, X-linked 4
BTG3 BTG family, member 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPE carboxypeptidase E
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EIF1 eukaryotic translation initiation factor 1
EPAS1 endothelial PAS domain protein 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BE histone cluster 1, H2be
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
MZB1 marginal zone B and B1 cell-specific protein
ORM1 orosomucoid 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
VTCN1 V-set domain containing T cell activation inhibitor 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
APMAP adipocyte plasma membrane associated protein
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BTBD3 BTB (POZ) domain containing 3
CANT1 calcium activated nucleotidase 1
CCND1 cyclin D1
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CENPB centromere protein B, 80kDa
CNPY2 canopy FGF signaling regulator 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EXOSC4 exosome component 4
FLNB filamin B, beta
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
GAS7 growth arrest-specific 7
GRWD1 glutamate-rich WD repeat containing 1
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KANK2 KN motif and ankyrin repeat domains 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
LTBP3 latent transforming growth factor beta binding protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1B microtubule-associated protein 1B
MBNL1 muscleblind-like splicing regulator 1
MBP myelin basic protein
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLEC malectin
MPRIP myosin phosphatase Rho interacting protein
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUDCD3 NudC domain containing 3
OXSR1 oxidative stress responsive 1
PCBP2 poly(rC) binding protein 2
PPAP2C phosphatidic acid phosphatase type 2C
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
PURA purine-rich element binding protein A
PYGB phosphorylase, glycogen; brain
RANBP6 RAN binding protein 6
RPP25 ribonuclease P/MRP 25kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEPT9 septin 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SF1 splicing factor 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SRSF11 serine/arginine-rich splicing factor 11
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2
SVIL supervillin
SYNM synemin, intermediate filament protein
TBC1D16 TBC1 domain family, member 16
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGOLN2 trans-golgi network protein 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TMEM43 transmembrane protein 43
TMF1 TATA element modulatory factor 1
TNS3 tensin 3
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
URI1 URI1, prefoldin-like chaperone
USP22 ubiquitin specific peptidase 22
VGLL4 vestigial-like family member 4
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
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