| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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377 genes differentially expressed following the BRD-K57080016_selumetinib_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABAT | 4-aminobutyrate aminotransferase |
| ACKR3 | atypical chemokine receptor 3 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric |
| ADIRF | adipogenesis regulatory factor |
| AHNAK2 | AHNAK nucleoprotein 2 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 |
| ALDOC | aldolase C, fructose-bisphosphate |
| ANXA4 | annexin A4 |
| ANXA9 | annexin A9 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 |
| ARMCX2 | armadillo repeat containing, X-linked 2 |
| ATF3 | activating transcription factor 3 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| BBS1 | Bardet-Biedl syndrome 1 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 |
| BEX1 | brain expressed, X-linked 1 |
| BLNK | B-cell linker |
| BST2 | bone marrow stromal cell antigen 2 |
| BTBD3 | BTB (POZ) domain containing 3 |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| BTG2 | BTG family, member 2 |
| C14ORF132 | chromosome 14 open reading frame 132 |
| C1R | complement component 1, r subcomponent |
| C1RL | complement component 1, r subcomponent-like |
| C9ORF3 | chromosome 9 open reading frame 3 |
| CAPN1 | calpain 1, (mu/I) large subunit |
| CAPN3 | calpain 3, (p94) |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCND2 | cyclin D2 |
| CCNG2 | cyclin G2 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 |
| CELF2 | CUGBP, Elav-like family member 2 |
| CES2 | carboxylesterase 2 |
| CFB | complement factor B |
| CFD | complement factor D (adipsin) |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
| CLU | clusterin |
| CNN1 | calponin 1, basic, smooth muscle |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 |
| COL14A1 | collagen, type XIV, alpha 1 |
| COL18A1 | collagen, type XVIII, alpha 1 |
| CPQ | carboxypeptidase Q |
| CRABP2 | cellular retinoic acid binding protein 2 |
| CRYAB | crystallin, alpha B |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 |
| DCN | decorin |
| DDR1 | discoidin domain receptor tyrosine kinase 1 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial |
| DES | desmin |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| EFNA1 | ephrin-A1 |
| EPHA3 | EPH receptor A3 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) |
| FAM134B | family with sequence similarity 134, member B |
| FAM63A | family with sequence similarity 63, member A |
| FDXR | ferredoxin reductase |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B |
| FOXO4 | forkhead box O4 |
| GAS1 | growth arrest-specific 1 |
| GATA6 | GATA binding protein 6 |
| GLUL | glutamate-ammonia ligase |
| GPM6B | glycoprotein M6B |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B |
| GSN | gelsolin |
| GSTA1 | glutathione S-transferase alpha 1 |
| GSTA4 | glutathione S-transferase alpha 4 |
| GSTM3 | glutathione S-transferase mu 3 (brain) |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HLA-E | major histocompatibility complex, class I, E |
| HMGN3 | high mobility group nucleosomal binding domain 3 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
| IFITM1 | interferon induced transmembrane protein 1 |
| IGFBP5 | insulin-like growth factor binding protein 5 |
| IGFBP6 | insulin-like growth factor binding protein 6 |
| IRF9 | interferon regulatory factor 9 |
| ISG15 | ISG15 ubiquitin-like modifier |
| JUN | jun proto-oncogene |
| JUP | junction plakoglobin |
| KLHL24 | kelch-like family member 24 |
| KRT15 | keratin 15, type I |
| LIMK2 | LIM domain kinase 2 |
| LMBRD1 | LMBR1 domain containing 1 |
| LTBP3 | latent transforming growth factor beta binding protein 3 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
| MAGED2 | melanoma antigen family D2 |
| MATN2 | matrilin 2 |
| MEF2C | myocyte enhancer factor 2C |
| METRN | meteorin, glial cell differentiation regulator |
| MSRB2 | methionine sulfoxide reductase B2 |
| MTSS1 | metastasis suppressor 1 |
| MUC1 | mucin 1, cell surface associated |
| MVP | major vault protein |
| MYL9 | myosin, light chain 9, regulatory |
| MYLK | myosin light chain kinase |
| NCAM1 | neural cell adhesion molecule 1 |
| NCK2 | NCK adaptor protein 2 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
| NEU1 | sialidase 1 (lysosomal sialidase) |
| NFIL3 | nuclear factor, interleukin 3 regulated |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| NOV | nephroblastoma overexpressed |
| NPEPL1 | aminopeptidase-like 1 |
| NRCAM | neuronal cell adhesion molecule |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| OBSL1 | obscurin-like 1 |
| OLFM4 | olfactomedin 4 |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 |
| OSBPL9 | oxysterol binding protein-like 9 |
| OSR2 | odd-skipped related transciption factor 2 |
| PBLD | phenazine biosynthesis-like protein domain containing |
| PBX1 | pre-B-cell leukemia homeobox 1 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PCP4 | Purkinje cell protein 4 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDGFC | platelet derived growth factor C |
| PDGFD | platelet derived growth factor D |
| PFKL | phosphofructokinase, liver |
| PFN2 | profilin 2 |
| PHYH | phytanoyl-CoA 2-hydroxylase |
| PIR | pirin (iron-binding nuclear protein) |
| PLA2G16 | phospholipase A2, group XVI |
| PLAGL1 | pleiomorphic adenoma gene-like 1 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 |
| PLN | phospholamban |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit |
| PPAP2A | phosphatidic acid phosphatase type 2A |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) |
| PROM1 | prominin 1 |
| PROS1 | protein S (alpha) |
| PRUNE2 | prune homolog 2 (Drosophila) |
| PYCARD | PYD and CARD domain containing |
| PYGL | phosphorylase, glycogen, liver |
| RABAC1 | Rab acceptor 1 (prenylated) |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 |
| RBKS | ribokinase |
| REEP1 | receptor accessory protein 1 |
| RPL31 | ribosomal protein L31 |
| RPS27L | ribosomal protein S27-like |
| SCPEP1 | serine carboxypeptidase 1 |
| SCRG1 | stimulator of chondrogenesis 1 |
| SELENBP1 | selenium binding protein 1 |
| SEPP1 | selenoprotein P, plasma, 1 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like |
| SH3YL1 | SH3 and SYLF domain containing 1 |
| SIDT2 | SID1 transmembrane family, member 2 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 |
| SORBS2 | sorbin and SH3 domain containing 2 |
| SOX2 | SRY (sex determining region Y)-box 2 |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SPAG4 | sperm associated antigen 4 |
| SPATA20 | spermatogenesis associated 20 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| STON1 | stonin 1 |
| SULF1 | sulfatase 1 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| SULT1A2 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 |
| TAGLN | transgelin |
| TM7SF2 | transmembrane 7 superfamily member 2 |
| TMEM135 | transmembrane protein 135 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TOX3 | TOX high mobility group box family member 3 |
| TPD52L1 | tumor protein D52-like 1 |
| TPM2 | tropomyosin 2 (beta) |
| TPP1 | tripeptidyl peptidase I |
| TPPP3 | tubulin polymerization-promoting protein family member 3 |
| TRIM2 | tripartite motif containing 2 |
| TRIM22 | tripartite motif containing 22 |
| TSC22D3 | TSC22 domain family, member 3 |
| TSPAN31 | tetraspanin 31 |
| TTC39A | tetratricopeptide repeat domain 39A |
| TXNIP | thioredoxin interacting protein |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) |
| VAV3 | vav 3 guanine nucleotide exchange factor |
| VCAM1 | vascular cell adhesion molecule 1 |
| YPEL5 | yippee-like 5 (Drosophila) |
| Symbol | Name |
|---|---|
| ACTN1 | actinin, alpha 1 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
| AMD1 | adenosylmethionine decarboxylase 1 |
| ANO1 | anoctamin 1, calcium activated chloride channel |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
| AREG | amphiregulin |
| ASF1B | anti-silencing function 1B histone chaperone |
| ASPH | aspartate beta-hydroxylase |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| ATAD2 | ATPase family, AAA domain containing 2 |
| AURKA | aurora kinase A |
| AURKB | aurora kinase B |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BOP1 | block of proliferation 1 |
| BRCA1 | breast cancer 1, early onset |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B |
| CCNA2 | cyclin A2 |
| CCNB1 | cyclin B1 |
| CCND1 | cyclin D1 |
| CCNF | cyclin F |
| CD3EAP | CD3e molecule, epsilon associated protein |
| CDC25A | cell division cycle 25A |
| CDC45 | cell division cycle 45 |
| CDC6 | cell division cycle 6 |
| CDCA4 | cell division cycle associated 4 |
| CDK1 | cyclin-dependent kinase 1 |
| CDK2 | cyclin-dependent kinase 2 |
| CENPA | centromere protein A |
| CENPE | centromere protein E, 312kDa |
| CENPF | centromere protein F, 350/400kDa |
| CENPN | centromere protein N |
| CENPU | centromere protein U |
| CEP55 | centrosomal protein 55kDa |
| COL4A1 | collagen, type IV, alpha 1 |
| COL4A2 | collagen, type IV, alpha 2 |
| DBF4 | DBF4 zinc finger |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 |
| DEPDC1 | DEP domain containing 1 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| DOCK4 | dedicator of cytokinesis 4 |
| DSCC1 | DNA replication and sister chromatid cohesion 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| ECT2 | epithelial cell transforming 2 |
| EIF4E | eukaryotic translation initiation factor 4E |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
| EPHA2 | EPH receptor A2 |
| ETV1 | ets variant 1 |
| ETV4 | ets variant 4 |
| ETV5 | ets variant 5 |
| EXO1 | exonuclease 1 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FANCI | Fanconi anemia, complementation group I |
| FASN | fatty acid synthase |
| FEN1 | flap structure-specific endonuclease 1 |
| FJX1 | four jointed box 1 (Drosophila) |
| FOSL1 | FOS-like antigen 1 |
| FOXM1 | forkhead box M1 |
| GAL | galanin/GMAP prepropeptide |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A |
| GTPBP4 | GTP binding protein 4 |
| GTSE1 | G-2 and S-phase expressed 1 |
| H2AFZ | H2A histone family, member Z |
| HBEGF | heparin-binding EGF-like growth factor |
| HELLS | helicase, lymphoid-specific |
| HJURP | Holliday junction recognition protein |
| HMGA1 | high mobility group AT-hook 1 |
| HMGA2 | high mobility group AT-hook 2 |
| HMGB2 | high mobility group box 2 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
| HSPA8 | heat shock 70kDa protein 8 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 |
| IER3 | immediate early response 3 |
| IGFBP3 | insulin-like growth factor binding protein 3 |
| INHBA | inhibin, beta A |
| ITGA6 | integrin, alpha 6 |
| ITGB5 | integrin, beta 5 |
| KIAA0101 | KIAA0101 |
| KIF11 | kinesin family member 11 |
| KIF14 | kinesin family member 14 |
| KIF15 | kinesin family member 15 |
| KIF18B | kinesin family member 18B |
| KRT18 | keratin 18, type I |
| KRT7 | keratin 7, type II |
| LIF | leukemia inhibitory factor |
| LIG1 | ligase I, DNA, ATP-dependent |
| LMNB1 | lamin B1 |
| LMNB2 | lamin B2 |
| LPL | lipoprotein lipase |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM2 | minichromosome maintenance complex component 2 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM7 | minichromosome maintenance complex component 7 |
| MELK | maternal embryonic leucine zipper kinase |
| MGLL | monoglyceride lipase |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
| MKI67 | marker of proliferation Ki-67 |
| MMP1 | matrix metallopeptidase 1 |
| MRTO4 | mRNA turnover 4 homolog (S. cerevisiae) |
| MSH2 | mutS homolog 2 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist |
| NCAPG | non-SMC condensin I complex, subunit G |
| NCAPG2 | non-SMC condensin II complex, subunit G2 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) |
| NET1 | neuroepithelial cell transforming 1 |
| NLRP2 | NLR family, pyrin domain containing 2 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
| NOP16 | NOP16 nucleolar protein |
| NRGN | neurogranin (protein kinase C substrate, RC3) |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| NUP205 | nucleoporin 205kDa |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| PBK | PDZ binding kinase |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PLAT | plasminogen activator, tissue |
| PLAU | plasminogen activator, urokinase |
| PLAUR | plasminogen activator, urokinase receptor |
| PLEK2 | pleckstrin 2 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 |
| PNP | purine nucleoside phosphorylase |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| PPAT | phosphoribosyl pyrophosphate amidotransferase |
| PRPF4 | pre-mRNA processing factor 4 |
| RAD51 | RAD51 recombinase |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RRM1 | ribonucleotide reductase M1 |
| RRM2 | ribonucleotide reductase M2 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) |
| S100A9 | S100 calcium binding protein A9 |
| SEH1L | SEH1-like (S. cerevisiae) |
| SFRP1 | secreted frizzled-related protein 1 |
| SH2B3 | SH2B adaptor protein 3 |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 |
| SPARCL1 | SPARC-like 1 (hevin) |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| SPRED2 | sprouty-related, EVH1 domain containing 2 |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| SPRY4 | sprouty homolog 4 (Drosophila) |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 |
| SRGN | serglycin |
| SRSF7 | serine/arginine-rich splicing factor 7 |
| STX1A | syntaxin 1A (brain) |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TESC | tescalcin |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TIPIN | TIMELESS interacting protein |
| TK1 | thymidine kinase 1, soluble |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) |
| TMEM2 | transmembrane protein 2 |
| TMPO | thymopoietin |
| TOP1 | topoisomerase (DNA) I |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPM4 | tropomyosin 4 |
| TPX2 | TPX2, microtubule-associated |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TSPAN5 | tetraspanin 5 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UCK2 | uridine-cytidine kinase 2 |
| UPP1 | uridine phosphorylase 1 |
| WWC1 | WW and C2 domain containing 1 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing |
| ZWINT | ZW10 interacting kinetochore protein |
