| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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165 genes differentially expressed following the BRD-K57080016_selumetinib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) |
| ACAA1 | acetyl-CoA acyltransferase 1 |
| ACAT2 | acetyl-CoA acetyltransferase 2 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 |
| AHNAK2 | AHNAK nucleoprotein 2 |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| APOE | apolipoprotein E |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 |
| BEX1 | brain expressed, X-linked 1 |
| BEX4 | brain expressed, X-linked 4 |
| BLNK | B-cell linker |
| C5 | complement component 5 |
| C6ORF62 | chromosome 6 open reading frame 62 |
| CALML5 | calmodulin-like 5 |
| CBS | cystathionine-beta-synthase |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha |
| CLDN8 | claudin 8 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial |
| CRYAB | crystallin, alpha B |
| CXCL12 | chemokine (C-X-C motif) ligand 12 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) |
| DMD | dystrophin |
| EFS | embryonal Fyn-associated substrate |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| FABP7 | fatty acid binding protein 7, brain |
| FADS2 | fatty acid desaturase 2 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) |
| FAM107A | family with sequence similarity 107, member A |
| FAM63A | family with sequence similarity 63, member A |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) |
| FOLR1 | folate receptor 1 (adult) |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
| GPER1 | G protein-coupled estrogen receptor 1 |
| GPM6B | glycoprotein M6B |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B |
| GSTA4 | glutathione S-transferase alpha 4 |
| HDAC6 | histone deacetylase 6 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) |
| HMOX1 | heme oxygenase 1 |
| HOXA5 | homeobox A5 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
| IGFBP3 | insulin-like growth factor binding protein 3 |
| KLF4 | Kruppel-like factor 4 (gut) |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| LMO2 | LIM domain only 2 (rhombotin-like 1) |
| LPL | lipoprotein lipase |
| LTF | lactotransferrin |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog |
| METTL7A | methyltransferase like 7A |
| NFIL3 | nuclear factor, interleukin 3 regulated |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| OPN3 | opsin 3 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDZK1 | PDZ domain containing 1 |
| PEBP1 | phosphatidylethanolamine binding protein 1 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| PPAP2B | phosphatidic acid phosphatase type 2B |
| PROM1 | prominin 1 |
| PYCARD | PYD and CARD domain containing |
| QKI | QKI, KH domain containing, RNA binding |
| QPRT | quinolinate phosphoribosyltransferase |
| REEP1 | receptor accessory protein 1 |
| S100P | S100 calcium binding protein P |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
| SESN1 | sestrin 1 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| TSKU | tsukushi, small leucine rich proteoglycan |
| VAT1 | vesicle amine transport 1 |
| YPEL5 | yippee-like 5 (Drosophila) |
| Symbol | Name |
|---|---|
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
| ACTN1 | actinin, alpha 1 |
| ADAM9 | ADAM metallopeptidase domain 9 |
| ADM | adrenomedullin |
| AEBP1 | AE binding protein 1 |
| AKAP12 | A kinase (PRKA) anchor protein 12 |
| ANXA3 | annexin A3 |
| AREG | amphiregulin |
| ASPH | aspartate beta-hydroxylase |
| CD47 | CD47 molecule |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CD9 | CD9 molecule |
| CEMIP | cell migration inducing protein, hyaluronan binding |
| COL10A1 | collagen, type X, alpha 1 |
| COL1A1 | collagen, type I, alpha 1 |
| CTGF | connective tissue growth factor |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| CXCL9 | chemokine (C-X-C motif) ligand 9 |
| CYR61 | cysteine-rich, angiogenic inducer, 61 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 |
| DUOX2 | dual oxidase 2 |
| DUSP6 | dual specificity phosphatase 6 |
| E2F2 | E2F transcription factor 2 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
| ENO2 | enolase 2 (gamma, neuronal) |
| EPHA2 | EPH receptor A2 |
| EREG | epiregulin |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
| FAT1 | FAT atypical cadherin 1 |
| FHL2 | four and a half LIM domains 2 |
| FILIP1L | filamin A interacting protein 1-like |
| FOSL1 | FOS-like antigen 1 |
| GDF15 | growth differentiation factor 15 |
| GLRX | glutaredoxin (thioltransferase) |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 |
| GSPT1 | G1 to S phase transition 1 |
| ICAM1 | intercellular adhesion molecule 1 |
| IDO1 | indoleamine 2,3-dioxygenase 1 |
| IER3 | immediate early response 3 |
| IGHD | immunoglobulin heavy constant delta |
| IGHM | immunoglobulin heavy constant mu |
| IGKV4-1 | immunoglobulin kappa variable 4-1 |
| IGLJ3 | immunoglobulin lambda joining 3 |
| IGLV3-19 | immunoglobulin lambda variable 3-19 |
| IL7R | interleukin 7 receptor |
| INPP1 | inositol polyphosphate-1-phosphatase |
| ITGB5 | integrin, beta 5 |
| KRT18 | keratin 18, type I |
| KRT8 | keratin 8, type II |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MALL | mal, T-cell differentiation protein-like |
| MET | MET proto-oncogene, receptor tyrosine kinase |
| MMP3 | matrix metallopeptidase 3 |
| MRPS12 | mitochondrial ribosomal protein S12 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 |
| NNMT | nicotinamide N-methyltransferase |
| NOP16 | NOP16 nucleolar protein |
| NOP56 | NOP56 ribonucleoprotein |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PNP | purine nucleoside phosphorylase |
| POU2AF1 | POU class 2 associating factor 1 |
| PROCR | protein C receptor, endothelial |
| PRPF4 | pre-mRNA processing factor 4 |
| RRM2 | ribonucleotide reductase M2 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 |
| SOD2 | superoxide dismutase 2, mitochondrial |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
| TFF3 | trefoil factor 3 (intestinal) |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TGFBI | transforming growth factor, beta-induced, 68kDa |
| THBS1 | thrombospondin 1 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TMEM2 | transmembrane protein 2 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A |
| TSPAN4 | tetraspanin 4 |
| TXN | thioredoxin |
| VCAN | versican |
