BRD-K57080016_selumetinib_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K57080016_selumetinib_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BMP4 bone morphogenetic protein 4
CBS cystathionine-beta-synthase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CRYAB crystallin, alpha B
CXCL14 chemokine (C-X-C motif) ligand 14
DEPTOR DEP domain containing MTOR-interacting protein
EFR3A EFR3 homolog A (S. cerevisiae)
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
GPNMB glycoprotein (transmembrane) nmb
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KRT15 keratin 15, type I
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
METTL7A methyltransferase like 7A
MGP matrix Gla protein
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRDX2 peroxiredoxin 2
RBBP7 retinoblastoma binding protein 7
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SULF1 sulfatase 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
AGR2 anterior gradient 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD40 CD40 molecule, TNF receptor superfamily member 5
COTL1 coactosin-like F-actin binding protein 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EGR1 early growth response 1
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FJX1 four jointed box 1 (Drosophila)
FKBP1A FK506 binding protein 1A, 12kDa
FOSL1 FOS-like antigen 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HPCAL1 hippocalcin-like 1
ICAM1 intercellular adhesion molecule 1
IL1B interleukin 1, beta
INHBB inhibin, beta B
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
LAMC2 laminin, gamma 2
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MLPH melanophilin
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS10 regulator of G-protein signaling 10
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT9 septin 9
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNAP25 synaptosomal-associated protein, 25kDa
SPON1 spondin 1, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TRIB2 tribbles pseudokinase 2
Funding