BRD-K57080016_selumetinib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K57080016_selumetinib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CBX1 chromobox homolog 1
CCNG2 cyclin G2
CSTA cystatin A (stefin A)
DYNLT3 dynein, light chain, Tctex-type 3
ELF5 E74-like factor 5 (ets domain transcription factor)
FAM63A family with sequence similarity 63, member A
GLS glutaminase
GPER1 G protein-coupled estrogen receptor 1
HEBP1 heme binding protein 1
HLA-DMA major histocompatibility complex, class II, DM alpha
IRX5 iroquois homeobox 5
ITFG1 integrin alpha FG-GAP repeat containing 1
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MB myoglobin
MXI1 MAX interactor 1, dimerization protein
NREP neuronal regeneration related protein
OSR2 odd-skipped related transciption factor 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PRSS8 protease, serine, 8
RAB9A RAB9A, member RAS oncogene family
SCPEP1 serine carboxypeptidase 1
SLC38A1 solute carrier family 38, member 1
SNX11 sorting nexin 11
TACSTD2 tumor-associated calcium signal transducer 2
TOB1 transducer of ERBB2, 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASPH aspartate beta-hydroxylase
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EGR3 early growth response 3
EPHB2 EPH receptor B2
EPYC epiphycan
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAT1 FAT atypical cadherin 1
GPX2 glutathione peroxidase 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB5 integrin, beta 5
LGALS4 lectin, galactoside-binding, soluble, 4
LIPG lipase, endothelial
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MUC2 mucin 2, oligomeric mucus/gel-forming
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAT plasminogen activator, tissue
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PYGL phosphorylase, glycogen, liver
RFC2 replication factor C (activator 1) 2, 40kDa
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TSPAN8 tetraspanin 8
Funding