BRD-K57080016_selumetinib_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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65 genes differentially expressed following the BRD-K57080016_selumetinib_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKAP12 A kinase (PRKA) anchor protein 12
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BHLHE41 basic helix-loop-helix family, member e41
CLGN calmegin
CYB5A cytochrome b5 type A (microsomal)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EPAS1 endothelial PAS domain protein 1
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
KLK6 kallikrein-related peptidase 6
MAL mal, T-cell differentiation protein
MID1IP1 MID1 interacting protein 1
MYL9 myosin, light chain 9, regulatory
MYRF myelin regulatory factor
NPR1 natriuretic peptide receptor 1
NXN nucleoredoxin
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDLIM1 PDZ and LIM domain 1
PIR pirin (iron-binding nuclear protein)
PROM1 prominin 1
PSCA prostate stem cell antigen
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
APLP2 amyloid beta (A4) precursor-like protein 2
BASP1 brain abundant, membrane attached signal protein 1
C4BPA complement component 4 binding protein, alpha
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIT citron rho-interacting serine/threonine kinase
CPB1 carboxypeptidase B1 (tissue)
CRLF1 cytokine receptor-like factor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ELF5 E74-like factor 5 (ets domain transcription factor)
EPHA3 EPH receptor A3
ETV1 ets variant 1
FAM129A family with sequence similarity 129, member A
FZD1 frizzled class receptor 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
IDO1 indoleamine 2,3-dioxygenase 1
KANK1 KN motif and ankyrin repeat domains 1
MALL mal, T-cell differentiation protein-like
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
NT5E 5'-nucleotidase, ecto (CD73)
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
RAD51C RAD51 paralog C
RGS13 regulator of G-protein signaling 13
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
STC1 stanniocalcin 1
STEAP3 STEAP family member 3, metalloreductase