BRD-K57169635_dacomitinib_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K57169635_dacomitinib_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ACSL3 acyl-CoA synthetase long-chain family member 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALG8 ALG8, alpha-1,3-glucosyltransferase
ANXA1 annexin A1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
CCR1 chemokine (C-C motif) receptor 1
CD93 CD93 molecule
CHN2 chimerin 2
CPVL carboxypeptidase, vitellogenic-like
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMTF1 cyclin D binding myb-like transcription factor 1
EDNRB endothelin receptor type B
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSN gelsolin
IFI44L interferon-induced protein 44-like
IGKC immunoglobulin kappa constant
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPT microtubule-associated protein tau
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
RGS5 regulator of G-protein signaling 5
RNFT1 ring finger protein, transmembrane 1
SOX9 SRY (sex determining region Y)-box 9
TBX3 T-box 3

decreased expression

Symbol Name
CA12 carbonic anhydrase XII
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CLU clusterin
CNIH4 cornichon family AMPA receptor auxiliary protein 4
CSTA cystatin A (stefin A)
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
FAM60A family with sequence similarity 60, member A
FGFR2 fibroblast growth factor receptor 2
FGFR4 fibroblast growth factor receptor 4
HOPX HOP homeobox
HOXB2 homeobox B2
HOXB6 homeobox B6
IGHM immunoglobulin heavy constant mu
LTBP1 latent transforming growth factor beta binding protein 1
MAOB monoamine oxidase B
MUC5B mucin 5B, oligomeric mucus/gel-forming
NPIPB3 nuclear pore complex interacting protein family, member B3
PEG3 paternally expressed 3
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PSPH phosphoserine phosphatase
PTCH1 patched 1
RBP1 retinol binding protein 1, cellular
SCGB2A1 secretoglobin, family 2A, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STAP1 signal transducing adaptor family member 1
TMEM45A transmembrane protein 45A
WT1 Wilms tumor 1
Funding