BRD-K57282030_JW-7-24-1_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K57282030_JW-7-24-1_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CD24 CD24 molecule
CD9 CD9 molecule
CFD complement factor D (adipsin)
CNN1 calponin 1, basic, smooth muscle
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CST1 cystatin SN
DENND2D DENN/MADD domain containing 2D
DUSP4 dual specificity phosphatase 4
ECHDC2 enoyl CoA hydratase domain containing 2
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
FBLN1 fibulin 1
GALC galactosylceramidase
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LITAF lipopolysaccharide-induced TNF factor
LOC100505650 uncharacterized LOC100505650
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS1 Meis homeobox 1
MMP1 matrix metallopeptidase 1
NGRN neugrin, neurite outgrowth associated
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFD platelet derived growth factor D
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRSS21 protease, serine, 21 (testisin)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASET2 ribonuclease T2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SPDEF SAM pointed domain containing ETS transcription factor
SQSTM1 sequestosome 1
SSPN sarcospan
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SWAP70 SWAP switching B-cell complex 70kDa subunit
TPP1 tripeptidyl peptidase I
TRAF5 TNF receptor-associated factor 5
TRIB1 tribbles pseudokinase 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
BIRC5 baculoviral IAP repeat containing 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
COL1A2 collagen, type I, alpha 2
COPS7A COP9 signalosome subunit 7A
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ELAVL1 ELAV like RNA binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
H2BFS H2B histone family, member S (pseudogene)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LMNB1 lamin B1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
LYZ lysozyme
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NUSAP1 nucleolar and spindle associated protein 1
PIH1D1 PIH1 domain containing 1
PLK1 polo-like kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SESN1 sestrin 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUB1 SUB1 homolog (S. cerevisiae)
TPX2 TPX2, microtubule-associated
TRIM2 tripartite motif containing 2
Funding