BRD-K57282030_JW-7-24-1_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K57282030_JW-7-24-1_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
CCNG2 cyclin G2
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CFD complement factor D (adipsin)
CLU clusterin
COBL cordon-bleu WH2 repeat protein
CSTA cystatin A (stefin A)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EZR ezrin
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5D lysine (K)-specific demethylase 5D
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
NT5E 5'-nucleotidase, ecto (CD73)
OLFM1 olfactomedin 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PITX1 paired-like homeodomain 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SMAD3 SMAD family member 3
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TP63 tumor protein p63
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
C2CD2 C2 calcium-dependent domain containing 2
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CDC25A cell division cycle 25A
CELF2 CUGBP, Elav-like family member 2
DEFB4A defensin, beta 4A
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENDOD1 endonuclease domain containing 1
GPX7 glutathione peroxidase 7
GSPT2 G1 to S phase transition 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
KIF5B kinesin family member 5B
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MEF2C myocyte enhancer factor 2C
MYH10 myosin, heavy chain 10, non-muscle
ODC1 ornithine decarboxylase 1
PI3 peptidase inhibitor 3, skin-derived
PLBD1 phospholipase B domain containing 1
PPIF peptidylprolyl isomerase F
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
RBP1 retinol binding protein 1, cellular
RNF144A ring finger protein 144A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD1 SMAD family member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TNPO1 transportin 1
TSPAN8 tetraspanin 8
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZEB1 zinc finger E-box binding homeobox 1
Funding