BRD-K57282030_JW-7-24-1_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K57282030_JW-7-24-1_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIPOR2 adiponectin receptor 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHGB chromogranin B
CSRP2 cysteine and glycine-rich protein 2
DCLK1 doublecortin-like kinase 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOXO3 forkhead box O3
GDF15 growth differentiation factor 15
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGB2 high mobility group box 2
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
KIAA1033 KIAA1033
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MYH11 myosin, heavy chain 11, smooth muscle
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL10 oxysterol binding protein-like 10
PCSK1 proprotein convertase subtilisin/kexin type 1
PLP1 proteolipid protein 1
PLTP phospholipid transfer protein
PSAP prosaposin
PSD3 pleckstrin and Sec7 domain containing 3
PTX3 pentraxin 3, long
RGS10 regulator of G-protein signaling 10
RNF13 ring finger protein 13
RSRP1 arginine/serine-rich protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TES testin LIM domain protein
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
TKTL1 transketolase-like 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRBC1 T cell receptor beta constant 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WSB1 WD repeat and SOCS box containing 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CDC25A cell division cycle 25A
DHCR24 24-dehydrocholesterol reductase
FAS Fas cell surface death receptor
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOXC1 forkhead box C1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HSPA1A heat shock 70kDa protein 1A
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KLK10 kallikrein-related peptidase 10
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LYZ lysozyme
MRPS2 mitochondrial ribosomal protein S2
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NPY1R neuropeptide Y receptor Y1
PLAC8 placenta-specific 8
PODXL podocalyxin-like
PROM1 prominin 1
RBM15B RNA binding motif protein 15B
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SELL selectin L
SEPT11 septin 11
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
TACSTD2 tumor-associated calcium signal transducer 2
VAT1 vesicle amine transport 1
Funding