BRD-K57457519_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K57457519_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATF3 activating transcription factor 3
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CD300A CD300a molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAIM Fas apoptotic inhibitory molecule
FCMR Fc fragment of IgM receptor
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
INA internexin neuronal intermediate filament protein, alpha
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JCHAIN joining chain of multimeric IgA and IgM
JUNB jun B proto-oncogene
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MYC v-myc avian myelocytomatosis viral oncogene homolog
NES nestin
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDZD2 PDZ domain containing 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PXDN peroxidasin
RGS1 regulator of G-protein signaling 1
RHOQ ras homolog family member Q
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SNX7 sorting nexin 7
SPTSSA serine palmitoyltransferase, small subunit A
STK10 serine/threonine kinase 10
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
UPP1 uridine phosphorylase 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CALR calreticulin
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNF cyclin F
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKB creatine kinase, brain
CRIP1 cysteine-rich protein 1 (intestinal)
CTSH cathepsin H
CTSZ cathepsin Z
DEFB1 defensin, beta 1
DMD dystrophin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FANCI Fanconi anemia, complementation group I
FASTKD5 FAST kinase domains 5
FGFR4 fibroblast growth factor receptor 4
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
LIG1 ligase I, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
NEFL neurofilament, light polypeptide
OLFML2A olfactomedin-like 2A
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RNASET2 ribonuclease T2
RPS11 ribosomal protein S11
SET SET nuclear proto-oncogene
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TPD52L1 tumor protein D52-like 1
TPX2 TPX2, microtubule-associated
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
ZNF586 zinc finger protein 586
Funding