BRD-K58479490_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

51 genes differentially expressed following the BRD-K58479490_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PID1 phosphotyrosine interaction domain containing 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SPON1 spondin 1, extracellular matrix protein
SREBF1 sterol regulatory element binding transcription factor 1
THBS1 thrombospondin 1
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
C1ORF106 chromosome 1 open reading frame 106
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MAP2K3 mitogen-activated protein kinase kinase 3
NIP7 NIP7, nucleolar pre-rRNA processing protein
PDGFA platelet-derived growth factor alpha polypeptide
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)