BRD-K59317601_INK-128_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K59317601_INK-128_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMDHD2 amidohydrolase domain containing 2
ANKRD36B ankyrin repeat domain 36B
C2CD5 C2 calcium-dependent domain containing 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHL1 cell adhesion molecule L1-like
CREB1 cAMP responsive element binding protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
GAB2 GRB2-associated binding protein 2
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSB glucuronidase, beta
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
LETMD1 LETM1 domain containing 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
N4BP2L2 NEDD4 binding protein 2-like 2
NAMPT nicotinamide phosphoribosyltransferase
PEG10 paternally expressed 10
PHIP pleckstrin homology domain interacting protein
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPAP2C phosphatidic acid phosphatase type 2C
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SPG11 spastic paraplegia 11 (autosomal recessive)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TSPAN1 tetraspanin 1
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
YME1L1 YME1-like 1 ATPase
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADGRL2 adhesion G protein-coupled receptor L2
AGA aspartylglucosaminidase
AK4 adenylate kinase 4
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ASS1 argininosuccinate synthase 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA2 carbonic anhydrase II
CCDC92 coiled-coil domain containing 92
CCL4 chemokine (C-C motif) ligand 4
CD58 CD58 molecule
CKAP4 cytoskeleton-associated protein 4
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DSC2 desmocollin 2
DSP desmoplakin
DYNLT3 dynein, light chain, Tctex-type 3
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LRRC59 leucine rich repeat containing 59
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL19 mitochondrial ribosomal protein L19
MSMO1 methylsterol monooxygenase 1
MUC16 mucin 16, cell surface associated
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
NUPL1 nucleoporin like 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PEG3 paternally expressed 3
PER2 period circadian clock 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PID1 phosphotyrosine interaction domain containing 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRDX4 peroxiredoxin 4
PRSS2 protease, serine, 2 (trypsin 2)
PYCR1 pyrroline-5-carboxylate reductase 1
RBP1 retinol binding protein 1, cellular
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPRR1B small proline-rich protein 1B
SQLE squalene epoxidase
SRGN serglycin
STC2 stanniocalcin 2
TCF4 transcription factor 4
TDG thymine-DNA glycosylase
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM47 transmembrane protein 47
TNS1 tensin 1
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VDAC1 voltage-dependent anion channel 1
VSNL1 visinin-like 1
XBP1 X-box binding protein 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZNF274 zinc finger protein 274
Funding