BRD-K59317601_INK-128_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

283 genes differentially expressed following the BRD-K59317601_INK-128_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACP5 acid phosphatase 5, tartrate resistant
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMIGO2 adhesion molecule with Ig-like domain 2
ARL8B ADP-ribosylation factor-like 8B
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP9A ATPase, class II, type 9A
BEX4 brain expressed, X-linked 4
C14ORF159 chromosome 14 open reading frame 159
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C2 complement component 2
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDC25B cell division cycle 25B
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CIRBP cold inducible RNA binding protein
CLIC5 chloride intracellular channel 5
CLN3 ceroid-lipofuscinosis, neuronal 3
COL11A1 collagen, type XI, alpha 1
CREBL2 cAMP responsive element binding protein-like 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSA cathepsin A
CTSB cathepsin B
CTSD cathepsin D
CTSL cathepsin L
CUTA cutA divalent cation tolerance homolog (E. coli)
CXCL9 chemokine (C-X-C motif) ligand 9
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP6 dual specificity phosphatase 6
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERP29 endoplasmic reticulum protein 29
EVI2A ecotropic viral integration site 2A
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GABARAP GABA(A) receptor-associated protein
GAS6 growth arrest-specific 6
GLS glutaminase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GMPR2 guanosine monophosphate reductase 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNS glucosamine (N-acetyl)-6-sulfatase
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LDOC1 leucine zipper, down-regulated in cancer 1
LEPROT leptin receptor overlapping transcript
LETMD1 LETM1 domain containing 1
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
LY96 lymphocyte antigen 96
LZTFL1 leucine zipper transcription factor-like 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K5 mitogen-activated protein kinase kinase 5
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL1A oxysterol binding protein-like 1A
OXA1L oxidase (cytochrome c) assembly 1-like
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBP2 poly(rC) binding protein 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
PLXNC1 plexin C1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PSAP prosaposin
QARS glutaminyl-tRNA synthetase
RBM47 RNA binding motif protein 47
RPL36 ribosomal protein L36
RRAGD Ras-related GTP binding D
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC38A2 solute carrier family 38, member 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TCEAL4 transcription elongation factor A (SII)-like 4
TCTA T-cell leukemia translocation altered
TGM2 transglutaminase 2
TMEM140 transmembrane protein 140
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRIM8 tripartite motif containing 8
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae)
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
UBXN1 UBX domain protein 1
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADGRL2 adhesion G protein-coupled receptor L2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
COASY CoA synthase
COTL1 coactosin-like F-actin binding protein 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNLT1 dynein, light chain, Tctex-type 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENOPH1 enolase-phosphatase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM107A family with sequence similarity 107, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFBP1 fibroblast growth factor binding protein 1
FSTL1 follistatin-like 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GEM GTP binding protein overexpressed in skeletal muscle
GFAP glial fibrillary acidic protein
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
ITGB1BP1 integrin beta 1 binding protein 1
ITM2A integral membrane protein 2A
IVL involucrin
KIF18B kinesin family member 18B
KLK10 kallikrein-related peptidase 10
LIPG lipase, endothelial
LMO4 LIM domain only 4
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPD3 non-SMC condensin II complex, subunit D3
NES nestin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPF4 pre-mRNA processing factor 4
PTN pleiotrophin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54L RAD54-like (S. cerevisiae)
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCRG1 stimulator of chondrogenesis 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHCBP1 SHC SH2-domain binding protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD1 SMAD family member 1
SMC1A structural maintenance of chromosomes 1A
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
TCTN1 tectonic family member 1
TK1 thymidine kinase 1, soluble
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
WSB2 WD repeat and SOCS box containing 2
WWTR1 WW domain containing transcription regulator 1
Funding