BRD-K59317601_INK-128_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K59317601_INK-128_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AREG amphiregulin
ATP9A ATPase, class II, type 9A
AZU1 azurocidin 1
BTG1 B-cell translocation gene 1, anti-proliferative
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CPB1 carboxypeptidase B1 (tissue)
CPM carboxypeptidase M
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CTSB cathepsin B
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNA1 ephrin-A1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSN gelsolin
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
IDS iduronate 2-sulfatase
IFNGR1 interferon gamma receptor 1
IL6ST interleukin 6 signal transducer
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JAG1 jagged 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MCOLN1 mucolipin 1
MEIS1 Meis homeobox 1
MET MET proto-oncogene, receptor tyrosine kinase
MXRA7 matrix-remodelling associated 7
NPC1 Niemann-Pick disease, type C1
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PAMR1 peptidase domain containing associated with muscle regeneration 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCOLCE procollagen C-endopeptidase enhancer
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PER1 period circadian clock 1
PLCB4 phospholipase C, beta 4
PLLP plasmolipin
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRSS23 protease, serine, 23
PTN pleiotrophin
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SIRT3 sirtuin 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAT1 vesicle amine transport 1
VIM vimentin
VNN1 vanin 1
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
AK4 adenylate kinase 4
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ASF1B anti-silencing function 1B histone chaperone
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CMC2 C-x(9)-C motif containing 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYTL1 cytokine-like 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGL2 fibrinogen-like 2
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GPR88 G protein-coupled receptor 88
GYG1 glycogenin 1
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
KIAA0101 KIAA0101
KLK11 kallikrein-related peptidase 11
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
LMNB1 lamin B1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYCBP MYC binding protein
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
PHGDH phosphoglycerate dehydrogenase
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCH protein kinase C, eta
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RFC2 replication factor C (activator 1) 2, 40kDa
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SAC3D1 SAC3 domain containing 1
SFN stratifin
SMC1A structural maintenance of chromosomes 1A
SPRR1A small proline-rich protein 1A
STRA13 stimulated by retinoic acid 13
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
UBE2C ubiquitin-conjugating enzyme E2C
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Funding