BRD-K59317601_INK-128_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K59317601_INK-128_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRE5 adhesion G protein-coupled receptor E5
AHR aryl hydrocarbon receptor
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP9A ATPase, class II, type 9A
AVPI1 arginine vasopressin-induced 1
BIK BCL2-interacting killer (apoptosis-inducing)
CCPG1 cell cycle progression 1
CPB1 carboxypeptidase B1 (tissue)
CPM carboxypeptidase M
CTGF connective tissue growth factor
CTSA cathepsin A
CTSB cathepsin B
CTSK cathepsin K
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCLK1 doublecortin-like kinase 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNMT histamine N-methyltransferase
IDE insulin-degrading enzyme
IFITM1 interferon induced transmembrane protein 1
IRS1 insulin receptor substrate 1
ITGAV integrin, alpha V
ITGB5 integrin, beta 5
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MCOLN1 mucolipin 1
MEIS1 Meis homeobox 1
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MXI1 MAX interactor 1, dimerization protein
MYOF myoferlin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NPC1 Niemann-Pick disease, type C1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFD platelet derived growth factor D
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PLD3 phospholipase D family, member 3
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLXNA1 plexin A1
PPAP2C phosphatidic acid phosphatase type 2C
PROM1 prominin 1
PRSS23 protease, serine, 23
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1CC1 RB1-inducible coiled-coil 1
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SIK1 salt-inducible kinase 1
SLC16A6 solute carrier family 16, member 6
SQSTM1 sequestosome 1
TCTN1 tectonic family member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VNN1 vanin 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CDC25A cell division cycle 25A
CKS2 CDC28 protein kinase regulatory subunit 2
CSTA cystatin A (stefin A)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HN1 hematological and neurological expressed 1
ICMT isoprenylcysteine carboxyl methyltransferase
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LMNB1 lamin B1
MAL mal, T-cell differentiation protein
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PXDN peroxidasin
RAD51C RAD51 paralog C
S100A10 S100 calcium binding protein A10
S100A9 S100 calcium binding protein A9
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLN sarcolipin
SRSF3 serine/arginine-rich splicing factor 3
STAT1 signal transducer and activator of transcription 1, 91kDa
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TFDP1 transcription factor Dp-1
TNNC1 troponin C type 1 (slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TTN titin
TYMS thymidylate synthetase
Funding