| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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83 genes differentially expressed following the BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ADIRF | adipogenesis regulatory factor |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) |
| ALOX5 | arachidonate 5-lipoxygenase |
| APOD | apolipoprotein D |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide |
| AURKA | aurora kinase A |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding |
| CBS | cystathionine-beta-synthase |
| CFD | complement factor D (adipsin) |
| CLU | clusterin |
| COMP | cartilage oligomeric matrix protein |
| CPD | carboxypeptidase D |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) |
| GLUL | glutamate-ammonia ligase |
| GOLGA8A | golgin A8 family, member A |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial |
| IL1R1 | interleukin 1 receptor, type I |
| KDM5D | lysine (K)-specific demethylase 5D |
| METTL7A | methyltransferase like 7A |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 |
| PHYH | phytanoyl-CoA 2-hydroxylase |
| PIR | pirin (iron-binding nuclear protein) |
| PRSS21 | protease, serine, 21 (testisin) |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 |
| RBP4 | retinol binding protein 4, plasma |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SEPP1 | selenoprotein P, plasma, 1 |
| SFN | stratifin |
| TNFSF13 | tumor necrosis factor (ligand) superfamily, member 13 |
| TNS1 | tensin 1 |
| TPD52L1 | tumor protein D52-like 1 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) |
| Symbol | Name |
|---|---|
| ADM | adrenomedullin |
| AIM2 | absent in melanoma 2 |
| CA1 | carbonic anhydrase I |
| CA2 | carbonic anhydrase II |
| CCDC47 | coiled-coil domain containing 47 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) |
| DUSP6 | dual specificity phosphatase 6 |
| EAF2 | ELL associated factor 2 |
| EGR1 | early growth response 1 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
| EXT1 | exostosin glycosyltransferase 1 |
| FAM57A | family with sequence similarity 57, member A |
| FN1 | fibronectin 1 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 |
| GADD45B | growth arrest and DNA-damage-inducible, beta |
| GATA3 | GATA binding protein 3 |
| GRWD1 | glutamate-rich WD repeat containing 1 |
| HSPA8 | heat shock 70kDa protein 8 |
| IDS | iduronate 2-sulfatase |
| IER2 | immediate early response 2 |
| KRT6B | keratin 6B, type II |
| LOC100505650 | uncharacterized LOC100505650 |
| MACF1 | microtubule-actin crosslinking factor 1 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| PLAT | plasminogen activator, tissue |
| PLK2 | polo-like kinase 2 |
| PON3 | paraoxonase 3 |
| PRKCA | protein kinase C, alpha |
| RND3 | Rho family GTPase 3 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) |
| SDC1 | syndecan 1 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 |
| SOX9 | SRY (sex determining region Y)-box 9 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| TLK2 | tousled-like kinase 2 |
| TMEM45A | transmembrane protein 45A |
| TRAPPC3 | trafficking protein particle complex 3 |
| TRIB2 | tribbles pseudokinase 2 |
| TUBB2A | tubulin, beta 2A class IIa |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 |
| XIST | X inactive specific transcript (non-protein coding) |
| XPO7 | exportin 7 |
