| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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136 genes differentially expressed following the BRD-K59369769_tozasertib_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| AAMDC | adipogenesis associated, Mth938 domain containing |
| ABAT | 4-aminobutyrate aminotransferase |
| ABHD4 | abhydrolase domain containing 4 |
| ACAT2 | acetyl-CoA acetyltransferase 2 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 |
| ALDOC | aldolase C, fructose-bisphosphate |
| AMDHD2 | amidohydrolase domain containing 2 |
| ASB13 | ankyrin repeat and SOCS box containing 13 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| BTG2 | BTG family, member 2 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CES1 | carboxylesterase 1 |
| CGA | glycoprotein hormones, alpha polypeptide |
| CLU | clusterin |
| COL8A2 | collagen, type VIII, alpha 2 |
| CRYAB | crystallin, alpha B |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| DHCR7 | 7-dehydrocholesterol reductase |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 |
| DSP | desmoplakin |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 |
| ELOVL6 | ELOVL fatty acid elongase 6 |
| FADS1 | fatty acid desaturase 1 |
| FADS2 | fatty acid desaturase 2 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 |
| FOXO1 | forkhead box O1 |
| GAB2 | GRB2-associated binding protein 2 |
| GM2A | GM2 ganglioside activator |
| GRN | granulin |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) |
| INSIG1 | insulin induced gene 1 |
| IRS2 | insulin receptor substrate 2 |
| ISYNA1 | inositol-3-phosphate synthase 1 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) |
| LDLR | low density lipoprotein receptor |
| LDOC1 | leucine zipper, down-regulated in cancer 1 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| METTL7A | methyltransferase like 7A |
| MME | membrane metallo-endopeptidase |
| MSMO1 | methylsterol monooxygenase 1 |
| NELL2 | NEL-like 2 (chicken) |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like |
| NTS | neurotensin |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PHYH | phytanoyl-CoA 2-hydroxylase |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PLXNC1 | plexin C1 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 |
| PTN | pleiotrophin |
| PXDN | peroxidasin |
| PYCARD | PYD and CARD domain containing |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SERINC5 | serine incorporator 5 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 |
| SQLE | squalene epoxidase |
| STX3 | syntaxin 3 |
| SULF1 | sulfatase 1 |
| TBX3 | T-box 3 |
| TCEAL2 | transcription elongation factor A (SII)-like 2 |
| TOX3 | TOX high mobility group box family member 3 |
| TRAPPC6A | trafficking protein particle complex 6A |
| TSC22D3 | TSC22 domain family, member 3 |
| TXNIP | thioredoxin interacting protein |
| ZMYND8 | zinc finger, MYND-type containing 8 |
| ZNF91 | zinc finger protein 91 |
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| ATAD2 | ATPase family, AAA domain containing 2 |
| AURKB | aurora kinase B |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BRCA1 | breast cancer 1, early onset |
| CCNA2 | cyclin A2 |
| CDC25A | cell division cycle 25A |
| CDK1 | cyclin-dependent kinase 1 |
| CENPU | centromere protein U |
| CIT | citron rho-interacting serine/threonine kinase |
| CKS1B | CDC28 protein kinase regulatory subunit 1B |
| COL1A2 | collagen, type I, alpha 2 |
| COL3A1 | collagen, type III, alpha 1 |
| COL6A3 | collagen, type VI, alpha 3 |
| CP | ceruloplasmin (ferroxidase) |
| CYCS | cytochrome c, somatic |
| DBF4 | DBF4 zinc finger |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 |
| DNM1L | dynamin 1-like |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 |
| HJURP | Holliday junction recognition protein |
| IFRD2 | interferon-related developmental regulator 2 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) |
| KIF14 | kinesin family member 14 |
| KIF15 | kinesin family member 15 |
| KIF18B | kinesin family member 18B |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MCM10 | minichromosome maintenance complex component 10 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NCAPG | non-SMC condensin I complex, subunit G |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) |
| ODC1 | ornithine decarboxylase 1 |
| PBK | PDZ binding kinase |
| PLK4 | polo-like kinase 4 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) |
| PRKD3 | protein kinase D3 |
| PROM1 | prominin 1 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 |
| RAD51AP1 | RAD51 associated protein 1 |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa |
| RGS2 | regulator of G-protein signaling 2 |
| RHOBTB3 | Rho-related BTB domain containing 3 |
| RRM2 | ribonucleotide reductase M2 |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SMC2 | structural maintenance of chromosomes 2 |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TGFBI | transforming growth factor, beta-induced, 68kDa |
| TMPO | thymopoietin |
| TRIP13 | thyroid hormone receptor interactor 13 |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| VRK1 | vaccinia related kinase 1 |
| ZWINT | ZW10 interacting kinetochore protein |
