BRD-K59469039_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K59469039_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CBS cystathionine-beta-synthase
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB2IP erbb2 interacting protein
EREG epiregulin
FAM134B family with sequence similarity 134, member B
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
HAMP hepcidin antimicrobial peptide
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGFBP3 insulin-like growth factor binding protein 3
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
MAPK13 mitogen-activated protein kinase 13
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFC platelet derived growth factor C
PHGDH phosphoglycerate dehydrogenase
PYCR1 pyrroline-5-carboxylate reductase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
WDR45 WD repeat domain 45
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
BAG3 BCL2-associated athanogene 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNF cyclin F
CDK6 cyclin-dependent kinase 6
CLU clusterin
CTSC cathepsin C
CXADR coxsackie virus and adenovirus receptor
CXCL5 chemokine (C-X-C motif) ligand 5
DACH1 dachshund family transcription factor 1
ESRRG estrogen-related receptor gamma
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6A glycoprotein M6A
H3F3B H3 histone, family 3B (H3.3B)
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
KIF20A kinesin family member 20A
KRT5 keratin 5, type II
LRRN3 leucine rich repeat neuronal 3
MCAM melanoma cell adhesion molecule
NFIB nuclear factor I/B
NTS neurotensin
PDE4B phosphodiesterase 4B, cAMP-specific
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PPL periplakin
PURA purine-rich element binding protein A
RASIP1 Ras interacting protein 1
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SYNM synemin, intermediate filament protein
TGFBR3 transforming growth factor, beta receptor III
TUBB4B tubulin, beta 4B class IVb
VWF von Willebrand factor